Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54029 МОЛЕКУЛЯРНАЯ БИОФИЗИКА И ФИЗИКА БИОМОЛЕКУЛ MOLECULAR BIOPHYSICS AND PHYSICS OF BIOMOLECULES МОЛЕКУЛЯРНАЯ БИОФИЗИКА И ФИЗИКА БИОМОЛЕКУЛ STATISTICAL THERMODYNAMICS TREATMENT FOR ANALYSIS OF BINDING BIOLOGICALLY ACTIVE COMPOUNDS TO NUCLEIC ACIDS ПРИМЕНЕНИЕ СТАТИСТИЧЕСКОЙ ТЕРМОДИНАМИКИ ДЛЯ АНАЛИЗА СВЯЗЫВАНИЯ БИОЛОГИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙ С НУКЛЕИНОВЫМИ КИСЛОТАМИ Нечипуренко Юрий Дмитриевич Nechipurenko Yuriy Dmitrievich nech99@mail.ru

доктор физико-математических наук;

doctor of physical and mathematical sciences;

 Институт молекулярной биологии им. В.А. Энгельгардта РАН Москва Россия Engelhardt Institute of Molecular Biology, Russian Academy of Sciences Moscow Russian Federation 25 06 2016 25 06 2016 1 1 204 207 20 06 2016 20 06 2016 https://rusjbpc.ru/en/nauka/article/54029/view

Связывание биологически активных соединений с нуклеиновыми кислотами необходимо рассматривать на основании представлений физической адсорбции. Применение модели Изинга позволяет построить аналитическое решение математических уравнений адсорбции в самом общем виде, для широкого класса моделей. Развитые нами подходы изложены в монографии, посвященной анализу связывания биологически активных соединений с нуклеиновыми кислотами.

The binding of biologically active compounds with nucleic acids should be described using the models of physical adsorption. The application of the Ising model allows to formulate an analytical solution of the mathematical equations of adsorption in the most general terms for a wide class of models. The developed approaches are outlined in the monograph addressing the analysis of biologically active compounds binding to the nucleic acids.

 связывание лигандов с ДНК кооперативные взаимодействия модели адсорбции модель Изинга DNA-ligand binding cooperative interactions binding curve Ising model

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