Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54055 НАНОБИОФИЗИКА NANOBIOPHYSICS НАНОБИОФИЗИКА BIOMIMETIC MONOLAYERS, FILMS AND MEMBRAN VESICLES BASED ON COMPLEXES OF AMPHIPHILIC SUBSTANCES, POLYMERS AND NANOPARTICLES БИОМИМЕТИЧЕСКИЕ МОНОСЛОИ, ПЛЕНКИ И МЕМБРАННЫЕ ВЕЗИКУЛЫ НА ОСНОВЕ КОМПЛЕКСОВ АМФИФИЛЬНЫХ ВЕЩЕСТВ, ПОЛИМЕРОВ И НАНОЧАСТИЦ Ким В П Kim V P vp.kim@physics.msu.ru Потапенков К В Potapenkov K V Ярославов А А Yaroslavov A A Сыбачин А В Sybatchin A V Таранов И В Taranov I V Черепенин В А Cherepenin V A Гуляев Ю В Gulyaev Yu V Хомутов Г Б Khomutov G B Московский государственный университет им. М.В. Ломоносова ru Lomonosov Moscow State University ru Московский государственный университет им. М.В. Ломоносова ru Lomonosov Moscow State University ru Московский государственный университет им. М.В. Ломоносова ru Lomonosov Moscow State University ru Московский государственный университет им. М.В. Ломоносова ru Lomonosov Moscow State University ru Институт радиотехники и электроники им. В.А. Котельникова РАН ru Kotel’nikov Institute of Radio Engineering and Electronics, Russian Academy of Sciences ru Институт радиотехники и электроники им. В.А. Котельникова РАН ru Kotel’nikov Institute of Radio Engineering and Electronics, Russian Academy of Sciences ru Институт радиотехники и электроники им. В.А. Котельникова РАН ru Kotel’nikov Institute of Radio Engineering and Electronics, Russian Academy of Sciences ru Московский государственный университет им. М.В. Ломоносова ru Lomonosov Moscow State University ru 25 12 2016 25 12 2016 1 2 24 29 20 12 2016 20 12 2016 https://rusjbpc.ru/en/nauka/article/54055/view

Создание новых функциональных биосовместимых и биоактивных материалов и эффективных систем для капсулирования, адресной доставки и управляемого высвобождения различных веществ в водных средах, в том числе в живых системах, является в настоящее время актуальной задачей биологической физики и химии, а также ряда смежных областей, решение которой важно для практических биомедицинских применений. В данной работе нами получены и охарактеризованы новые нанокомпозитные биомиметические функциональные наносистемы на основе пленок Ленгмюра-Блоджетт, а также везикулы и капсулы на основе мембранных комплексов, включающих липиды, функциональные аминосодержащие амфифильные соединения, полимеры (в том числе биополимеры) и функциональные неорганические наночастицы (Fe3O4 и Au). Исследования проводились методами просвечивающей электронной микроскопии, атомно-силовой микроскопии, электронного парамагнитного резонанса.

Creation of new functional biocompatible and bioactive materials and efficient systems for the encapsulation, drug delivery and controlled release of various substances in water environments, including in live systems, is an actual task of biophysics and chemistry and also for a number of allied sciences, solution of which is essential important for practical biomedical applications. In this work we have prepared and characterized novel nanocomposite biomimetic functional nanosystems on the basis Langmuir-Blodgett films, vesicles or capsules on the basis membrane complexes including lipids functional aminocontaining amphiphilic compounds, polymers (including biopolymers) and functional inorganic nanoparticles (Fe3O4 and Au). The fabricated systems have been investigated using transmission electron microscopy, atomic_force microscopy, electron paramagnetic resonance.

 биомиметические наноструктуры липосомы ДНК наночастицы магнетита biomimetic nanostructures liposomes DNA nanoparticles of magnetite

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