Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54061 НАНОБИОФИЗИКА NANOBIOPHYSICS НАНОБИОФИЗИКА CERIUM OXIDE NANOPARTICLES ARE NOT TOXIC FOR HUMAN MESENCHYMAL STEM CELLS AND ARE ABLE TO STIMULATE THEIR PROLIFERATION IN VITRO НАНОЧАСТИЦЫ ДИОКСИДА ЦЕРИЯ НЕ ЯВЛЯЮТСЯ ТОКСИЧНЫМИ ДЛЯ МСК ЧЕЛОВЕКА И СПОСОБНЫ СТИМУЛИРОВАТЬ ИХ ПРОЛИФЕРАЦИЮ IN VITRO Попов А Л Popov A L antonpopovleonid@gmail.com Попова Н Р Popova N R Иванов В К Ivanov V K Институт теоретической и экспериментальной биофизики РАН ru Institute of theoretical and experimental biophysics RAS ru Институт теоретической и экспериментальной биофизики РАН ru Institute of theoretical and experimental biophysics RAS ru Институт общей и неорганической химии им. Н.С. Курнакова РАН ru Kurnakov institute of general and inorganic chemistry RAS ru 25 12 2016 25 12 2016 1 2 47 51 20 12 2016 20 12 2016 https://rusjbpc.ru/en/nauka/article/54061/view

Разработка и синтез новых функциональных наноматериалов для биомедицинских целей требует обязательного проведения комплексной оценки их токсичности в условиях in vitro и in vivo . В данной работе проведен анализ агрегативной устойчивости нового типа наночастиц диоксида церия, допированных гадолинием, а также проведено исследование их влияния на пролиферативную и метаболическую активность МСК человека in vitro . Показано, что наночастицы диоксида церия не является токсичными в широком диапазоне концентраций (10-5-10-9 М), а также способны стимулировать пролиферацию МСК человека в дозозависимой манере. Высокая степень биосовместимости и низкая токсичность синтезированных наноматериалов позволяют говорить о перспективности разработки биомедицинских препаратов на их основе.

Design and synthesis of new nanomaterials for biomedical applications require a comprehensive assessment of their toxicity in vitro and in vivo . We analyzed the aggregate stability of new types of cerium oxide nanoparticles doped with gadolinium and checked their influence on the proliferative and metabolic activity of human fibroblast in vitro . It has been shown that cerium oxide nanoparticles are not toxic in a wide range of concentrations (10- 5-10-9 M), and are able to stimulate proliferation of the human MSCs in a dose-dependent manner. The high degree of biocompatibility and low toxicity of synthesized nanomaterials allow us to consider it as perspective compound for development of biomedical products.

 наночастицы диоксида церия пролиферативная активность МСК человека cerium oxide nanoparticles proliferative activity human mesenchymal stem cells

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