Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54080 БИООРГАНИЧЕСКАЯ, БИОФИЗИЧЕСКАЯ И МЕДИЦИНСКАЯ ХИМИЯ BIOORGANIC, BIOPHYSICAL AND MEDICINAL CHEMISTRY БИООРГАНИЧЕСКАЯ, БИОФИЗИЧЕСКАЯ И МЕДИЦИНСКАЯ ХИМИЯ FEATURES OF ACCUMULATION AND DISTRIBUTION OF SMALLSIZED ZINC COMPOUNDS IN THE EXPERIMENT ON RATS НАКОПЛЕНИЯ И РАСПРЕДЕЛЕНИЯ МАЛОРАЗМЕРНЫХ СОЕДИНЕНИЙ ЦИНКА В ЭКСПЕРИМЕНТЕ НА КРЫСАХ Ларин С Л Larin S L sergeilarin.kursk@gmail.com Будко Е В Budko E V Хабаров А А Khabarov A A Курский государственный медицинский университет ru Kursk state medical university ru Курский государственный медицинский университет ru Kursk state medical university ru Курский государственный медицинский университет ru Kursk state medical university ru 25 12 2016 25 12 2016 1 2 119 123 20 12 2016 20 12 2016 https://rusjbpc.ru/en/nauka/article/54080/view

Проведено сравнительное изучение in vivo накопления и распределения малоразмерных соединений цинка: Zn(OH)2 (размер частиц 2-3 нм, далее - ZN-НЧ), ZnO (размер частиц 1,0-0,9 мкм, далее - ZN-МЧ) полученных модифицированным конденсационным методом . Эксперимент проведен в четырех группах крыс Wistar, определение содержания Zn2+ проводилось методом атомно-абсорбционной спектрометрии (ААС) после внутрижелудочного введения один раз в сутки в течение 7 дней. Выявлен сопоставимый уровень всасывания и накопления растворимых и нерастворимых малоразмерных соединений цинка. Обнаружена повышенная экскрекция наноразмерных частиц.

We have carried out a comparative in vivo study of accumulation and distribution of smallsized zinc compounds: Zn(OH)2 (the size of particles - 2-3 nm, further - ZN-NP), ZnO (the size of particles - 1,0-0,9 μm, further - ZN-MP) received by the modified condensation method. The experiment was carried out in four groups of Wistar rats, the content of Zn2+ was determined by the method of atomic absorption spectrometry (AAS) after intragastric injection once a day during 7 days. The comparable level of absorption and accumulation of soluble and insoluble small zinc compounds has been detected. The increased excretion of nanoparticles has been detected.

 наночастицы малоразмерные формы нерастворимые соединения цинка сульфат цинка оксид цинка гидроксид цинка ААС крысы Wistar распределение в тканях внутрижелудочное ведение nanoparticles small-size forms insoluble zinc compounds zinc sulfate zinc oxide zinc hydroxide AAS Wistar rats tissue distribution intragastric injection

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