Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54162 МОЛЕКУЛЯРНАЯ БИОФИЗИКА И ФИЗИКА БИОМОЛЕКУЛ MOLECULAR BIOPHYSICS AND PHYSICS OF BIOMOLECULES МОЛЕКУЛЯРНАЯ БИОФИЗИКА И ФИЗИКА БИОМОЛЕКУЛ 5-lipoxygenase inhibitors modulate Ca2+ responses induced by trifluoperazine in macrophages Ингибиторы 5-липоксигеназ модулируют Са2+-ответы, вызываемые трифлуоперазином в макрофагах Миленина Л С Milenina L S cozzy@mail.ru Крутецкая З И Krutetskaya Z I Наумова А А Naumova A A Бутов С Н Butov S N Крутецкая Н И Krutetskaya N I Антонов В Г Antonov V G Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru 25 06 2017 25 06 2017 2 1 239 243 20 06 2017 20 06 2017 https://rusjbpc.ru/en/nauka/article/54162/view

С использованием флуоресцентного Са2+-зонда Fura-2AM впервые показано, что специфические ингибиторы 5-липоксигеназ зилеутон и каффеиковая кислота существенно подавляют Са2+-ответы, индуцируемые нейролептиком трифлуоперазином, в макрофагах. Результаты свидетельствуют об участии 5-липоксигеназ и/или продуктов 5-липоксигеназного пути окисления арахидоновой кислоты во влиянии трифлуоперазина на внутриклеточную концентрацию Са2+ в макрофагах.

Using Fura-2AM microfluorimetry it was shown for the first time that 5-lipoxygenase specific inhibitors zileuton and caffeic acid significantly inhibit Ca2+ responses, induced by neuroleptic trifluoperazine, in macrophages. The results suggest the involvement of 5-lipoxygenases and/or products of 5-lipoxygenase pathway of arachidonic acid cascade in the effect of trifluoperazine on intracellular Ca2+ concentration in macrophages.

 трифлуоперазин 5-липоксигеназы макрофаги trifluoperazine 5-lipoxygenases macrophages

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