Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54170 МОЛЕКУЛЯРНАЯ БИОФИЗИКА И ФИЗИКА БИОМОЛЕКУЛ MOLECULAR BIOPHYSICS AND PHYSICS OF BIOMOLECULES МОЛЕКУЛЯРНАЯ БИОФИЗИКА И ФИЗИКА БИОМОЛЕКУЛ The effect of neuroleptics on Na+ transport in frog skin Влияние нейролептиков на транспорт Na+ в коже лягушки Мельницкая А В Melnitskaya A V avmelnitskaya@yandex.ru Крутецкая З И Krutetskaya Z I Бутов С Н Butov S N Крутецкая Н И Krutetskaya N I Антонов В Г Antonov V G Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru 25 06 2017 25 06 2017 2 1 272 275 20 06 2017 20 06 2017 https://rusjbpc.ru/en/nauka/article/54170/view

С использованием метода фиксации потенциала исследовано влияние двух структурно различных нейролептиков галоперидола и хлорпромазина на транспорт Na+ в коже лягушки. Впервые показано, что галоперидол и хлорпромазин модулируют трансэпителиальный транспорт Na+. Полученные результаты свидетельствуют также о том, что регуляторное влияние данных антипсихотических агентов на транспорт Na+ в коже лягушки осуществляется при участии различных сигнальных механизмов.

Using voltage-clamp technique, the influence of two structurally different neuroleptics haloperidol and chlorpromazine on Na+ transport in frog skin was investigated. It was shown for the first time that haloperidol and chlorpromazine modulate the transepithelial Na+ transport. The results obtained also suggest that the regulatory effect of these antipsychotic agents on Na+ transport in frog skin is mediated by distinct signaling mechanisms.

 кожа лягушки трансэпителиальный транспорт Na+ галоперидол хлорпромазин frog skin transepithelial Na+ transport haloperidol chlorpromazine

Наточин Ю.В. Основы физиологии почки. Л.: Наука, 1982, 184 с. [Natochin, Yu.V. Fundamentals of kidney physiology. Leningrad: Nauka, 1982, 184 p. (In Russ.)] Natochin Yu.V. Osnovy fiziologii pochki. L.: Nauka, 1982, 184 s. [Natochin, Yu.V. Fundamentals of kidney physiology. Leningrad: Nauka, 1982, 184 p. (In Russ.)] Oruch R., Lund A., Pryme I.F., Holmsen H. An intercalation mechanism as a mode of action exerted by psychotropic drugs: results of altered phospholipid substrate availabilities in membranes? J. Chem. Biol., 2010, vol. 3, pp. 67-88. Oruch R., Lund A., Pryme I.F., Holmsen H. An intercalation mechanism as a mode of action exerted by psychotropic drugs: results of altered phospholipid substrate availabilities in membranes? J. Chem. Biol., 2010, vol. 3, pp. 67-88. Dilsaver S.C. Antipsychotic agents: a review. Am. Fam. Phys., 1993, vol. 47, pp. 199-204. Dilsaver S.C. Antipsychotic agents: a review. Am. Fam. Phys., 1993, vol. 47, pp. 199-204. Van Dyke R.W., Scharschmidt B.F. Effects of chlorpromazine on Na+-K+-ATPase pumping and solute transport in rat hepatocytes. Am. J. Physiol., 1987, vol. 253, pp. 613-621. Van Dyke R.W., Scharschmidt B.F. Effects of chlorpromazine on Na+-K+-ATPase pumping and solute transport in rat hepatocytes. Am. J. Physiol., 1987, vol. 253, pp. 613-621. Else P., Mansfield K. Activiation of sodium transport and intracellular sodium lowering by the neuroleptic drug chlorpromazine. Biochem. Pharmacol., 1997, vol. 54, pp. 275-281. Else P., Mansfield K. Activiation of sodium transport and intracellular sodium lowering by the neuroleptic drug chlorpromazine. Biochem. Pharmacol., 1997, vol. 54, pp. 275-281. Awayda M.S., Shao W., Guo F., Zeidel M., Hill W.G. ENaC - Membrane interactions: regulation of channel activity by membrane order. J. Gen. Physiol., 2004, vol. 123, pp. 709-727. Awayda M.S., Shao W., Guo F., Zeidel M., Hill W.G. ENaC - Membrane interactions: regulation of channel activity by membrane order. J. Gen. Physiol., 2004, vol. 123, pp. 709-727. Cobos E.J., Entrena J.M., Nieto F.R., Cendán C.M., Del Pozo E. Pharmacology and therapeutic potential of sigma(1) receptor ligands. Curr. Neuropharmacol., 2008, vol. 6, pp. 344-366. Cobos E.J., Entrena J.M., Nieto F.R., Cendán C.M., Del Pozo E. Pharmacology and therapeutic potential of sigma(1) receptor ligands. Curr. Neuropharmacol., 2008, vol. 6, pp. 344-366. Cobos E.J., Del Pozo E., Baeyens J.M. Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells. J. Neurochem., 2007, vol. 102, pp. 812-825. Cobos E.J., Del Pozo E., Baeyens J.M. Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells. J. Neurochem., 2007, vol. 102, pp. 812-825. Rousseaux C.G., Greene S.F. Sigma receptors [σRs]: biology in normal and diseased states. J. Recept. Signal. Trans., 2016, vol. 36, pp. 327-388. Rousseaux C.G., Greene S.F. Sigma receptors [σRs]: biology in normal and diseased states. J. Recept. Signal. Trans., 2016, vol. 36, pp. 327-388. Hellewell S.B., Bruce A., Feinstein G., Orringer J., Williams W., Bowen W.D. Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling. Eur. J. Pharmacol., 1994, vol. 268, pp. 9-18. Hellewell S.B., Bruce A., Feinstein G., Orringer J., Williams W., Bowen W.D. Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling. Eur. J. Pharmacol., 1994, vol. 268, pp. 9-18. Su T.-P., Hayashi T., Maurice T., Buch S., Ruoho A.E. The sigma-1 receptor chaperone as an inter-organelle signaling modulator. Trends Pharmacol. Sci., 2010, vol. 31, pp. 557-566. Su T.-P., Hayashi T., Maurice T., Buch S., Ruoho A.E. The sigma-1 receptor chaperone as an inter-organelle signaling modulator. Trends Pharmacol. Sci., 2010, vol. 31, pp. 557-566. Carnally S.M., Johannessen M., Henderson R.M., Jackson M.B., Edwardson J. M. Demonstration of a direct interaction between σ-1 receptors and acid-sensing ion channels. Biophys. J., 2010, vol. 98, pp. 1182-1191. Carnally S.M., Johannessen M., Henderson R.M., Jackson M.B., Edwardson J. M. Demonstration of a direct interaction between σ-1 receptors and acid-sensing ion channels. Biophys. J., 2010, vol. 98, pp. 1182-1191.