Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54267 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ AMINAZINE MODULATES THE EFFECT OF IMMUNOMODULATOR GLUTOXIM ON Na+ TRANSPORT IN FROG SKIN АМИНАЗИН МОДУЛИРУЕТ ВЛИЯНИЕ ИММУНОМОДУЛЯТОРА ГЛУТОКСИМА НА ТРАНСПОРТ Na+ В КОЖЕ ЛЯГУШКИ Мельницкая А В Melnitskaya A V avmelnitskaya@yandex.ru Крутецкая З И Krutetskaya Z I Бутов С Н Butov S N Крутецкая Н И Krutetskaya N I Антонов В Г Antonov V G Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru Санкт-Петербургский государственный университет ru Saint-Petersburg State University ru 25 03 2018 25 03 2018 3 1 196 199 20 03 2018 20 03 2018 https://rusjbpc.ru/en/nauka/article/54267/view

С использованием метода фиксации потенциала исследовали участие сигма-1 рецепторов в регуляции глутоксимом транспорта Na+ в коже лягушки. Показано, что обработка кожи лягушки антагонистом рецепторов сигма-1 аминазином подавляет стимулирующее влияние глутоксима на транспорт Na+. Полученные результаты свидетельствуют о возможном участии рецепторов сигма-1 в регуляции глутоксимом транспорта Na+ в коже лягушки.

Using voltage-clamp technique, the involvement of sigma-1 receptors in the effect of glutoxim on Na+ transport in frog skin was investigated. We have shown that preincubation of the frog skin with sigma-1 receptor antagonist - aminazine - attenuates the stimulatory effect of glutoxim on Na+ transport. The results suggest the possible involvement of the sigma-1 receptors in glutoxim effect on Na+ transport in frog skin epithelium.

 кожа лягушки трансэпителиальный транспорт Na+ глутоксим аминазин frog skin transepithelial Na+ transport glutoxim aminazine

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