Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54291 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ POSSIBILITIES OF APPLICATION OF SALIVA FTIR-SPECTROSCOPY FOR THE DIAGNOSIS OF CANCER ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ ИК-ФУРЬЕ-СПЕКТРОСКОПИИ СЛЮНЫ ДЛЯ ДИАГНОСТИКИ ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ Бельская Л В Bel’skaya L V Ludab2005@mail.ru Сарф Е А Sarf E A Омский государственный педагогический университет ru Omsk State Pedagogical University ru Омский государственный педагогический университет ru Omsk State Pedagogical University ru 25 06 2018 25 06 2018 3 2 343 349 20 06 2018 20 06 2018 https://rusjbpc.ru/en/nauka/article/54291/view

Показана принципиальная возможность диагностики рака легкого и молочной железы с использованием метода ИК-Фурье-спектроскопии. Статистически достоверные отличия для ИК-спектров слюны больных раком легкого наблюдаются в спектральном диапазоне 1070-1240 см-1 и могут быть отнесены к нуклеиновым кислотам. Для группы пациентов с раком молочной железы отличий в спектрах значительно больше: различаются по интенсивности полосы поглощения фосфодиэфирных групп, нуклеиновых кислот и фосфолипидов (1300 и 800 см-1), метильных и метиленовых групп молекул белков, липидов, а также карбоксильных групп жирных кислот и аминокислот (1500-1300 см-1), ДНК и РНК (1700-1580 см-1), а также метильных и метиленовых групп насыщенных и ненасыщенных алкильных цепей (3050-2800 см-1). Выявлены коэффициенты I1398/1454 и I1240/1310, изменение которых на фоне онкологической патологии статистически достоверно.

The basic possibility of diagnosing lung and breast cancer using the method of IR Fourier spectroscopy is shown. Statistically significant differences for infrared spectra of saliva in patients with lung cancer are observed in the spectral range of 1070-1240 cm-1 and can be attributed to nucleic acids. For the group of patients with breast cancer, the differences in the spectra are significantly larger: absorption bands of phosphodiester groups, nucleic acids and phospholipids (1300 and 800 cm-1), methyl and methylene groups of protein molecules, lipids, and carboxyl groups of fatty acids and amino acids (1500 -1300 cm-1), DNA and RNA (1700-1580 cm-1), as well as methyl and methylene groups of saturated and unsaturated alkyl chains (3050-2800 cm-1) differ in intensity. Coefficients revealed I1398/1454 and I1240/1310, whose change against the background of oncological pathology is statistically significant.

 слюна инфракрасная спектроскопия диагностика рак легкого рак молочной железы saliva infrared spectroscopy diagnosis lung cancer breast cancer

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