Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54297 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ BIOPHYSICAL AND MOLECULAR MECHANISMS OF REDOX REGULATION OF TUMOR CELLS CHEMORESISTANCE БИОФИЗИЧЕСКИЕ И МОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ РЕДОКС-РЕГУЛЯЦИИ ХИМИОРЕЗИСТЕНТНОСТИ ОПУХОЛЕВЫХ КЛЕТОК Мартинович Г Г Martinovich G G martinovichgg@bsu.by Мартинович И В Martinovich I V Вчерашняя А В Vcherashniaya A V Зенков Н К Zenkov N K Меньщикова Е Б Menshchikova E B lemen@centercem.ru Черенкевич С Н Cherenkevich S N Белорусский государственный университет ru Belarusian State University ru Белорусский государственный университет ru Belarusian State University ru Белорусский государственный университет ru Belarusian State University ru Федеральный исследовательский центр фундаментальной и трансляционной медицины ru Federal Research Centre fundamental and translational medicine ru Федеральный исследовательский центр фундаментальной и трансляционной медицины ru Federal Research Centre fundamental and translational medicine ru Белорусский государственный университет ru Belarusian State University ru 25 06 2018 25 06 2018 3 2 379 383 20 06 2018 20 06 2018 https://rusjbpc.ru/en/nauka/article/54297/view

В работе представлены собственные и литературные данные о биофизических и молекулярных механизмах регуляции химиорезистентности опухолевых клеток, протекающих с участием активных форм кислорода и антиоксидантов. Рассматриваются также механизмы редокс-сигнализации и регуляции редокс-гомеостаза в нормальных и опухолевых клетках. Особое внимание уделено новым стратегиям снижения лекарственной устойчивости опухолевых клеток, базирующимся на редокс-регуляции клеточных процессов.

The work provides own and literature data about molecular and biophysical mechanisms of regulation of tumor cells chemoresistance that occur with the participation of reactive oxygen species and antioxidants. The mechanisms of redox signaling and redox homeostasis regulation in normal and tumor cells are considered. Special attention is given to the new strategies for reduction of drug resistance in tumor cells based on redox regulation of cellular processes.

 химиорезистентность антиоксиданты активные формы кислорода опухолевые клетки редокс-регуляция редокс-сигнализация chemoresistance antioxidants reactive oxygen species tumor cells redox regulation redox signaling

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