Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54320 Общая биофизика General biophysics Общая биофизика TALKING ABOUT THE ISOTOPIC EFFECTS OF HEAVY WATER IN BIOLOGICAL AND MODEL SYSTEMS О ЧЕМ ГОВОРЯТ ИЗОТОПНЫЕ ЭФФЕКТЫ ТЯЖЕЛОЙ ВОДЫ В БИОЛОГИЧЕСКИХ И МОДЕЛЬНЫХ СИСТЕМАХ Лобышев В. И. Lobyshev V. I. lobyshev@yandex.ru Московский государственный университет имени М.В. Ломоносова Москва Россия Lomonosov Moscow State University Moscow Russian Federation 25 09 2018 25 09 2018 3 3 511 519 20 09 2018 20 09 2018 https://rusjbpc.ru/en/nauka/article/54320/view

Дан обзор работ по изотопным эффектам, связанным с заменой обычной воды на тяжелую. Отмечены наиболее общие признаки биологических изотопных эффектов - адаптация, ингибирование биохимических и физиологических реакций, увеличенная стабильность к высокой температуре и другим внешним экстремальным условиям, замедление биологических часов, быстрота появления эффектов. Особое внимание уделено неожиданным эффектам малых концентраций дейтерия в воде и в воде с пониженным содержанием дейтерия.

The review is given for the isotopic effects of D2O. The general features of the biological isotope effects are pointed out - adaptation, inhibition of biochemical and physiological reactions, increased stability to high temperature and other external extremal conditions, deceleration of biological clocks, high speed of the effects appearance. Special attention is paid to unexpected effects of small concentrations of deuterium in water and deuterium depleted water.

 D2O вода с пониженным содержанием дейтерия живые организмы клетки биополимеры deuterium depleted water living organisms cells biopolymers

Lewis G.N. The biochemistry of water containing hydrogen isotope. J. Amer. Chem. Soc., 1933, vol. 55, no. 8, pр. 3503-3504. Lewis G.N. The biochemistry of water containing hydrogen isotope. J. Amer. Chem. Soc., 1933, vol. 55, no. 8, pr. 3503-3504. Taylor H.S., Swingle W.W., Eyring H., Frost A.A. The effect of water containing the isotope of hydrogen upon fresh water organisms. J. Cell Comp. Physiol., 1933, vol. 4, no. 1, p.1-8. Taylor H.S., Swingle W.W., Eyring H., Frost A.A. The effect of water containing the isotope of hydrogen upon fresh water organisms. J. Cell Comp. Physiol., 1933, vol. 4, no. 1, p.1-8. Lewis G.N. The biology of heavy water. Science, 1934, no. 2042, pp. 151-153. Lewis G.N. The biology of heavy water. Science, 1934, no. 2042, pp. 151-153. Crespi H.L., Archer S.M., Katz J.J. Cultivation of microorganisms in heavy water. Nature, 1959, vol. 184, no. 4687, pp. 729-730. Crespi H.L., Archer S.M., Katz J.J. Cultivation of microorganisms in heavy water. Nature, 1959, vol. 184, no. 4687, pp. 729-730. Хлебович В.В. Акклимация животных организмов. Л: Наука, 1981, 136 с. [Khlebovich V.V. Acclimation of animal organisms. L: Nauka, 1981, 136 p. (In Russ.)] Hlebovich V.V. Akklimaciya zhivotnyh organizmov. L: Nauka, 1981, 136 s. [Khlebovich V.V. Acclimation of animal organisms. L: Nauka, 1981, 136 p. (In Russ.)] Рогинский С.З., Шноль С.Э. Изотопы в биохимии. М: Изд. АН СССР, 1963, 380 с. [Roginsky S.Z., Shnoll S.E. Isotopes in biochemistry. М: AS USSR, 1963, 380 p. (In Russ.)] Roginskiy S.Z., Shnol' S.E. Izotopy v biohimii. M: Izd. AN SSSR, 1963, 380 s. [Roginsky S.Z., Shnoll S.E. Isotopes in biochemistry. M: AS USSR, 1963, 380 p. (In Russ.)] Лобышев В.И., Калиниченко Л.П. Изотопные эффекты D2O в биологических системах. М., Наука, 1978, 213 с. [Lobyshev V.I., Kalinichenko L.P. Isotope effects of D2O jn biological systems. М., Nauka, 1978, 213 p. (In Russ.)] Lobyshev V.I., Kalinichenko L.P. Izotopnye effekty D2O v biologicheskih sistemah. M., Nauka, 1978, 213 s. [Lobyshev V.I., Kalinichenko L.P. Isotope effects of D2O jn biological systems. M., Nauka, 1978, 213 p. (In Russ.)] Никитин Д.И., Оранская М.Н., Лобышев В.И. Специфичность отклика бактерий на вариации изотопного состава воды. Биофизика, 2003, т. 48, вып. 4, с. 678-682. [Nikitin D.I., Oranskaya M.N., Lobyshev V.I. The specificity of response of bacteria to variations in the isotopic content of water. Biophysics, 2003, vol. 48, no. 4, pp. 678-682. (In Russ.)] Nikitin D.I., Oranskaya M.N., Lobyshev V.I. Specifichnost' otklika bakteriy na variacii izotopnogo sostava vody. Biofizika, 2003, t. 48, vyp. 4, s. 678-682. [Nikitin D.I., Oranskaya M.N., Lobyshev V.I. The specificity of response of bacteria to variations in the isotopic content of water. Biophysics, 2003, vol. 48, no. 4, pp. 678-682. (In Russ.)] Косенков А.В., Гуляев М.В., Лобышев В.И., Юсубалиева Г.М., Баклаушев В.П. Обратимое дейтерирование тканевой жидкости и биополимеров в нормальных и опухолевых тканях мышей. Биофизика, 2018, т. 63, вып. 4. [Kosenkov A.V., Gulaev M.V., Lobyshev V.I. [et al.] Reversible Deuterium Exchange of Tissue Fluid and Biopolymers in Normal and Tumor Tissue of Mice. Biophysics, 2018, vol. 63, no. 4 (In Russ.)] Kosenkov A.V., Gulyaev M.V., Lobyshev V.I., Yusubalieva G.M., Baklaushev V.P. Obratimoe deyterirovanie tkanevoy zhidkosti i biopolimerov v normal'nyh i opuholevyh tkanyah myshey. Biofizika, 2018, t. 63, vyp. 4. [Kosenkov A.V., Gulaev M.V., Lobyshev V.I. [et al.] Reversible Deuterium Exchange of Tissue Fluid and Biopolymers in Normal and Tumor Tissue of Mice. Biophysics, 2018, vol. 63, no. 4 (In Russ.)] Lobyshev V.I., Gianic T., Masarova M. Сhanges in vesicular membrans ESR spin label parameters upon isotope solvent substitution. General Physiology and Biophysics, 1987, no. 6, pp. 297-302. Lobyshev V.I., Gianic T., Masarova M. Shanges in vesicular membrans ESR spin label parameters upon isotope solvent substitution. General Physiology and Biophysics, 1987, no. 6, pp. 297-302. Lobyshev V.I. Proton inventory method in thermodynamics of heat transition in biopolymers. In “Water and Ions in Biological Systems”. Ed. By P. Lauger, L. Packer, V. Vasilescu. Birkhauser Verlag, Basel, 1988, рр. 381-386. Lobyshev V.I. Proton inventory method in thermodynamics of heat transition in biopolymers. In “Water and Ions in Biological Systems”. Ed. By P. Lauger, L. Packer, V. Vasilescu. Birkhauser Verlag, Basel, 1988, rr. 381-386. Лобышев В.И., Вишневская З.И. Анализ кинетических изотопных эффектов в смесях Н2О-D2О в ферментативном катализе. Способ выявления роли конформационно-динамических процессов. Биофизика, 1984, т. 29, вып. 2, с. 184-189. [Lobyshev V.I., Vishnevskaya Z.I. Analysis of kinetic isotope effects in H2O- D2O mixtures in the enzyme catalysis - detection of conformational-dynamic processes. Biophysics, 1984, vol. 29, no. 2, p. 184-189. (In Russ.)] Lobyshev V.I., Vishnevskaya Z.I. Analiz kineticheskih izotopnyh effektov v smesyah N2O-D2O v fermentativnom katalize. Sposob vyyavleniya roli konformacionno-dinamicheskih processov. Biofizika, 1984, t. 29, vyp. 2, s. 184-189. [Lobyshev V.I., Vishnevskaya Z.I. Analysis of kinetic isotope effects in H2O- D2O mixtures in the enzyme catalysis - detection of conformational-dynamic processes. Biophysics, 1984, vol. 29, no. 2, p. 184-189. (In Russ.)] Gurwitch A.G. Hystologischen Grundlagen der Biologie, Iena, Fisher, 1930, pp. 310. Gurwitch A.G. Hystologischen Grundlagen der Biologie, Iena, Fisher, 1930, pp. 310. Lobyshev V.I., Li Qingguo, Cheng Jiji. The solvent isotopic effect of heavy water on kinetics of the intermediates M412 and O640 of bacteriorhodopsin photocycle. J. Fudan Univ. (Natural Sci.), China, 1990, vоl. 29, no. 3, pp. 327-334. Lobyshev V.I., Li Qingguo, Cheng Jiji. The solvent isotopic effect of heavy water on kinetics of the intermediates M412 and O640 of bacteriorhodopsin photocycle. J. Fudan Univ. (Natural Sci.), China, 1990, vol. 29, no. 3, pp. 327-334. Ферронский В.И., Поляков В.А. Изотопия гидросферы Земли. М., Научный мир, 2009, 632 с. [Ferronsky V.I., Polyakov V.A. Isotopy of the Earth hydrosphere. М., Nauchny mir, 2009, 632 p. (In Russ.)] Ferronskiy V.I., Polyakov V.A. Izotopiya gidrosfery Zemli. M., Nauchnyy mir, 2009, 632 s. [Ferronsky V.I., Polyakov V.A. Isotopy of the Earth hydrosphere. M., Nauchny mir, 2009, 632 p. (In Russ.)] Barnes T.C. A possible physiological effect of the heavy isotope of H in water. J. Amer. Chem. Soc., 1933, vol. 55, no. 10, pp. 4332-4333. Barnes T.C. A possible physiological effect of the heavy isotope of H in water. J. Amer. Chem. Soc., 1933, vol. 55, no. 10, pp. 4332-4333. Barnes T.C. Futher observation on the physiological effect on the heavy hydrogen isotope on Spirogyra. Amer. J. Botany, 1933, vol. 20, no. 10, p. 181-182. Barnes T.C. Futher observation on the physiological effect on the heavy hydrogen isotope on Spirogyra. Amer. J. Botany, 1933, vol. 20, no. 10, p. 181-182. Barnes T.C., Larson E.J. Futher experiments on the physiological effect of heavy water and of ice water. J. Amer. Chem. Soc., 1933, vol. 55, no. 12, pp. 5059-5060. Barnes T.C., Larson E.J. Futher experiments on the physiological effect of heavy water and of ice water. J. Amer. Chem. Soc., 1933, vol. 55, no. 12, pp. 5059-5060. Barnes T.C. The effect of heavy water of low concentration on Euglena. Science, 1934, vol. 79, no. 2050, p. 370. Barnes T.C. The effect of heavy water of low concentration on Euglena. Science, 1934, vol. 79, no. 2050, p. 370. Barnes T.C. Alleged simulation of moulds by paraffin in heavy water. Nature, 1934, vol. 134, no. 3389, pp. 573-574. Barnes T.C. Alleged simulation of moulds by paraffin in heavy water. Nature, 1934, vol. 134, no. 3389, pp. 573-574. Barnes T.C., Larson E.J. The effect of heavy water of low concentration on Spirogyra, Planaria and enzyme action. Protoplasma, 1934, Bd. 22, H. 3, pp. 431-443. Barnes T.C., Larson E.J. The effect of heavy water of low concentration on Spirogyra, Planaria and enzyme action. Protoplasma, 1934, Bd. 22, H. 3, pp. 431-443. Barnes T.C., Jahn T.L. Properties of water of biological interest. Quart. Rev. Biol., 1934, vol. 9, no. 3, pp. 292-341. Barnes T.C., Jahn T.L. Properties of water of biological interest. Quart. Rev. Biol., 1934, vol. 9, no. 3, pp. 292-341. Barnes T.C., Gaw H.Z. The chemical basis for some biological effects of heavy water. J. Amer. Chem. Soc., 1935, vol. 57, no. 3, pp. 590-591. Barnes T.C., Gaw H.Z. The chemical basis for some biological effects of heavy water. J. Amer. Chem. Soc., 1935, vol. 57, no. 3, pp. 590-591. Richards O.W. The growth of yeast in water containing deuterium. Amer. J. Botany, 1933, vol. 20, no. 10, pp. 679-680. Richards O.W. The growth of yeast in water containing deuterium. Amer. J. Botany, 1933, vol. 20, no. 10, pp. 679-680. Richards O.W. The effect of deuterium on the growth of yeast. J. Bacter., 1934, vol. 28, no. 3, pp. 289-294. Richards O.W. The effect of deuterium on the growth of yeast. J. Bacter., 1934, vol. 28, no. 3, pp. 289-294. Mayer S.L. Alleged stimulation of moulds by paraffin in heavy water. Nature, 1934, vol. 134, no. 3391, p. 665. Mayer S.L. Alleged stimulation of moulds by paraffin in heavy water. Nature, 1934, vol. 134, no. 3391, p. 665. Mayer S.L. Deuterium oxide and Aspergillus. Science, 1934, vol. 79, no. 2044, pp. 210-211. Mayer S.L. Deuterium oxide and Aspergillus. Science, 1934, vol. 79, no. 2044, pp. 210-211. Macht D.I., Davis M.E. Some pharmacological experiments with deuterium. J. Amer. Chem. Soc., 1934, vol. 56, no. 1, p. 246. Macht D.I., Davis M.E. Some pharmacological experiments with deuterium. J. Amer. Chem. Soc., 1934, vol. 56, no. 1, p. 246. Fox D.L., Cupp E.E., McEwen G.F. Low concentration of deuterium oxide and the growth of marine diatoms. Proc. Soc. Expl. Biol. Med., 1936, vol. 34, no. 5, pp. 575-581. Fox D.L., Cupp E.E., McEwen G.F. Low concentration of deuterium oxide and the growth of marine diatoms. Proc. Soc. Expl. Biol. Med., 1936, vol. 34, no. 5, pp. 575-581. Rea C.E., Yuster S. Effect of deuterium oxide on rat sarcoma R-39. Proc. Soc. Expl. Biol. Med., 1934, vol. 39, no. 9, pp. 1058-1060. Rea C.E., Yuster S. Effect of deuterium oxide on rat sarcoma R-39. Proc. Soc. Expl. Biol. Med., 1934, vol. 39, no. 9, pp. 1058-1060. Shoup C.S., Mayer S.L. The action of deuterium oxide in low concentration on the course of gas production by brewer’s yeast. J. Tennessee Acad. Sci., 1935, vol. 10, no. 2, pp. 127-130. Shoup C.S., Mayer S.L. The action of deuterium oxide in low concentration on the course of gas production by brewer’s yeast. J. Tennessee Acad. Sci., 1935, vol. 10, no. 2, pp. 127-130. Larson E.J., BarnesT.C. Parasition in heavy water of low concentration. Nature, 1934, vol. 133, no. 3371, pp. 873-874. Larson E.J., BarnesT.C. Parasition in heavy water of low concentration. Nature, 1934, vol. 133, no. 3371, pp. 873-874. Terao A., Inoue Y. Effect of the heavy water on the population growth of the water-flee, Moina macrocopa strauss. Proc. Imp. Acad. (Tokyo), 1934, vol. 10, no. 8, pp. 513-514. Terao A., Inoue Y. Effect of the heavy water on the population growth of the water-flee, Moina macrocopa strauss. Proc. Imp. Acad. (Tokyo), 1934, vol. 10, no. 8, pp. 513-514. Brun J., Tronstad L. Some germination experiments with peas in heavy water. K. Norske Vidensk. Selik. Fozhandl (Trondheim), 1935, vol. 7, (paper 48), pp. 171-173. Brun J., Tronstad L. Some germination experiments with peas in heavy water. K. Norske Vidensk. Selik. Fozhandl (Trondheim), 1935, vol. 7, (paper 48), pp. 171-173. Curry J., Pratt R., Trelease S.F. Does dilute heavy water influence biological processes. Science, 1935, vol. 81, pp. 275-277. Curry J., Pratt R., Trelease S.F. Does dilute heavy water influence biological processes. Science, 1935, vol. 81, pp. 275-277. Weiser H.H. Influence of deuterium oxide on growth and morphology on lactobacilli. Proc. Soc. Expl. Biol. Med., 1937, vol. 36, no. 2, pp. 151-152. Weiser H.H. Influence of deuterium oxide on growth and morphology on lactobacilli. Proc. Soc. Expl. Biol. Med., 1937, vol. 36, no. 2, pp. 151-152. Fox D.L. Concerning enzymic reactions in heavy water. J. Cell. Comp. Physiol., 1935, vol. 6, no. 3, pp. 405-424. Fox D.L. Concerning enzymic reactions in heavy water. J. Cell. Comp. Physiol., 1935, vol. 6, no. 3, pp. 405-424. Ewart A.J. The influence of heavy water on plants. J. Exp. Biol. Med., 1935, vol. 13, no. 1, pp. 9-15. Ewart A.J. The influence of heavy water on plants. J. Exp. Biol. Med., 1935, vol. 13, no. 1, pp. 9-15. Родимов Б.Н. Снеговая вода - стимулятор роста и продуктивности животных и растений. Сельское хоз. Сибири, Омск, 1961, № 7б, с. 66-69. [Rodimov B.N. Water from snow - stimulator for growth and productivity of animals and plants. Selskoe khozyajstvo Sibiri, Omsk, 1961, no. 7б, pp. 66-69. (In Russ.)] Rodimov B.N. Snegovaya voda - stimulyator rosta i produktivnosti zhivotnyh i rasteniy. Sel'skoe hoz. Sibiri, Omsk, 1961, № 7b, s. 66-69. [Rodimov B.N. Water from snow - stimulator for growth and productivity of animals and plants. Selskoe khozyajstvo Sibiri, Omsk, 1961, no. 7b, pp. 66-69. (In Russ.)] Родимов Б.Н., Маршунина А., Яфарова И. Действие снеговой воды на живые организмы. Сельскохозяйственное производство Сибири и Дальнего Востока. Омск, 1965, № 4, с. 56-57. [Rodimov B.N., Marshunina A., Yafarova I. The influence of snow water on living organisms. Selskokhozyastvennoe proizvodstvo Sibiri I Dalnego Vostoka, Omsk, 1965, no. 4, pp. 56-57. (In Russ.)] Rodimov B.N., Marshunina A., Yafarova I. Deystvie snegovoy vody na zhivye organizmy. Sel'skohozyaystvennoe proizvodstvo Sibiri i Dal'nego Vostoka. Omsk, 1965, № 4, s. 56-57. [Rodimov B.N., Marshunina A., Yafarova I. The influence of snow water on living organisms. Selskokhozyastvennoe proizvodstvo Sibiri I Dalnego Vostoka, Omsk, 1965, no. 4, pp. 56-57. (In Russ.)] Торопцев И.В., Родимов Б.Н., Маршунина А.М., Яфарова И.О., Садовникова В.И., Лобина И.Г. Биологическая роль тяжлой воды в живых организмах. Вопросы радиобиологии и гематологии. Изд. Томского ун-та, 1966, с. 118-126. [Toroptsev I.V., Rodimov B.N., Marshunina A. [et al.] Biological role of heavy water in biological systems. Voprosy radiobiologii I gematologii, Tomsk, Tomsk Univ., 1966, pp. 118-126. (In Russ.)] Toropcev I.V., Rodimov B.N., Marshunina A.M., Yafarova I.O., Sadovnikova V.I., Lobina I.G. Biologicheskaya rol' tyazhloy vody v zhivyh organizmah. Voprosy radiobiologii i gematologii. Izd. Tomskogo un-ta, 1966, s. 118-126. [Toroptsev I.V., Rodimov B.N., Marshunina A. [et al.] Biological role of heavy water in biological systems. Voprosy radiobiologii I gematologii, Tomsk, Tomsk Univ., 1966, pp. 118-126. (In Russ.)] Gleason J.D., Friedman I. Oats may grow better in water depleted in oxygen-18 and deuterium. Nature, 1975, vol. 256, no. 5505, p. 305. Gleason J.D., Friedman I. Oats may grow better in water depleted in oxygen-18 and deuterium. Nature, 1975, vol. 256, no. 5505, p. 305. Лобышев В.И., Твердислов В.А., Яковенко Л.В., Фогель Ю. Активирование Na, K-ATФазы малыми концентрациями D2О, ингибирование-большими. Биофизика, 1978, т. 23, вып. 2, с. 390-391. [Lobyshev V.I., Tverdislov V.A., Vogel J., Yakovenko L.V. Activation of Na, K-ATPase by low concentrations of D2О, inhibition by high-concentrations. Biophysics, 1978, vol. 23, no. 2, pp. 390-391. (In Russ.)] Lobyshev V.I., Tverdislov V.A., Yakovenko L.V., Fogel' Yu. Aktivirovanie Na, K-ATFazy malymi koncentraciyami D2O, ingibirovanie-bol'shimi. Biofizika, 1978, t. 23, vyp. 2, s. 390-391. [Lobyshev V.I., Tverdislov V.A., Vogel J., Yakovenko L.V. Activation of Na, K-ATPase by low concentrations of D2O, inhibition by high-concentrations. Biophysics, 1978, vol. 23, no. 2, pp. 390-391. (In Russ.)] Лобышев В.И., Фогель Ю., Яковенко Л.В., Резаева М.Н., Твердислов В.А. D2О как модификатор ионной специфичности Na, K-АТФазы. Биофизика, 1982, т. 27, вып. 4, с. 595-603. [Lobyshev V.I., Vogel J., Yakovenko L.V., Rezaeva M.N., Tverdislov V.A. D2О as a modifier of ionic specificity of Na,K-ATPase. Biophysics, 1982, vol. 27, no. 4, p. 595-603. (In Russ.)] Lobyshev V.I., Fogel' Yu., Yakovenko L.V., Rezaeva M.N., Tverdislov V.A. D2O kak modifikator ionnoy specifichnosti Na, K-ATFazy. Biofizika, 1982, t. 27, vyp. 4, s. 595-603. [Lobyshev V.I., Vogel J., Yakovenko L.V., Rezaeva M.N., Tverdislov V.A. D2O as a modifier of ionic specificity of Na,K-ATPase. Biophysics, 1982, vol. 27, no. 4, p. 595-603. (In Russ.)] Лобышев В.И. Аномальное активирующее влияние тяжелой воды малой концентрации на регенерацию гидроидных полипов. Биофизика, 1983, т. 28, вып. 4, с. 666-668. [Lobyshev V.I. Activating influence of small concentration heavy water on the regeneration of hydroid polyp Obelia geniculata. Biophysics, 1983, vol. 28, no. 4, pp. 666-668. (In Russ.)] Lobyshev V.I. Anomal'noe aktiviruyuschee vliyanie tyazheloy vody maloy koncentracii na regeneraciyu gidroidnyh polipov. Biofizika, 1983, t. 28, vyp. 4, s. 666-668. [Lobyshev V.I. Activating influence of small concentration heavy water on the regeneration of hydroid polyp Obelia geniculata. Biophysics, 1983, vol. 28, no. 4, pp. 666-668. (In Russ.)] Мельников И.А., Лобышев В.И. Фракционирование 18O в снежно-ледяном покрове центрального арктического бассейна. Океанология, 1985, № 2, с. 237-241. [Melnikov I.A., Lobyshev V.I. Fractionating of 18O within snow-ice cover in the central Arctic Ocean. Okeanologiya, 1985, no. 2, pp. 237-241. (In Russ.)] Mel'nikov I.A., Lobyshev V.I. Frakcionirovanie 18O v snezhno-ledyanom pokrove central'nogo arkticheskogo basseyna. Okeanologiya, 1985, № 2, s. 237-241. [Melnikov I.A., Lobyshev V.I. Fractionating of 18O within snow-ice cover in the central Arctic Ocean. Okeanologiya, 1985, no. 2, pp. 237-241. (In Russ.)] Лобышев В.И., Мельников И.А., Есиков А.Д., Нечаев В.В. Исследование изотопного состава кислорода арктического дрейфующего льда в связи с проблемой активации роста микроорганизмов на границе тающего льда. Биофизика, 1984, т. 29, вып. 5, с. 835-839. [Lobyshev V.I., Melnikov I.A., Esikov A.D., Nechaev V.V. Biophysics, 1984, vol. 29, no. 5, pp. 835-839. (In Russ.)] Lobyshev V.I., Mel'nikov I.A., Esikov A.D., Nechaev V.V. Issledovanie izotopnogo sostava kisloroda arkticheskogo dreyfuyuschego l'da v svyazi s problemoy aktivacii rosta mikroorganizmov na granice tayuschego l'da. Biofizika, 1984, t. 29, vyp. 5, s. 835-839. [Lobyshev V.I., Melnikov I.A., Esikov A.D., Nechaev V.V. Biophysics, 1984, vol. 29, no. 5, pp. 835-839. (In Russ.)] Николаев С.Д. Изотопно-кислородная палеотермия мирового океана в мезо-кайнозое. Состояние проблемы. В кн.: VII Всес. Симп. по стабильным изотопам в геохимии. М., изд. АН СССР, 1978, с. 317-319. [Nikolaev S.D. Isotope-oxygen paleothermy of global ocean in meso-Cenozoic. Status of the problem. In.: VII Vses. Symp. po Stabilnym isotopam v geohimii. М., AN USSR, 1978, pp. 317-319. (In Russ.)] Nikolaev S.D. Izotopno-kislorodnaya paleotermiya mirovogo okeana v mezo-kaynozoe. Sostoyanie problemy. V kn.: VII Vses. Simp. po stabil'nym izotopam v geohimii. M., izd. AN SSSR, 1978, s. 317-319. [Nikolaev S.D. Isotope-oxygen paleothermy of global ocean in meso-Cenozoic. Status of the problem. In.: VII Vses. Symp. po Stabilnym isotopam v geohimii. M., AN USSR, 1978, pp. 317-319. (In Russ.)] Somlyai G., Janeso G., Jakli G., Vass K., Barna B., Lakies V., Gaal T. Naturally occurring deuterium is essential for the normal growth rate of cells. FEBS, 1993, vol. 317, no. 1-2, pp. 1-4. Somlyai G., Janeso G., Jakli G., Vass K., Barna B., Lakies V., Gaal T. Naturally occurring deuterium is essential for the normal growth rate of cells. FEBS, 1993, vol. 317, no. 1-2, pp. 1-4. Somlyai G., Laskay G., Berkenyi T., Galbacs Z., Galbacs G., Kiss S.A., Jakli Gy., Jancso G. The biological effects of deuterium - depleted water, a possible new tool in cancer therapy. Z. Oncol./J. Oncol. 1998, vol. 30, no. 4, pp. 91-94. Somlyai G., Laskay G., Berkenyi T., Galbacs Z., Galbacs G., Kiss S.A., Jakli Gy., Jancso G. The biological effects of deuterium - depleted water, a possible new tool in cancer therapy. Z. Oncol./J. Oncol. 1998, vol. 30, no. 4, pp. 91-94. Сыроешкин А.В., Титорович О.В., Плетнева Т.В., Бурдейная Т.Н. Вода, обедненная по дейтерию, как адъювантное средство при лечении онкологических заболеваний. Микроэлементы в медицине, 2015, т. 16, № 3, с. 29-37. [Syroeshkin A.V., Titorovich O.V., Pletneva T.V., Byrdejnaya T.N. Water depleted of deuterium as aduvant remedy for cancer therapy. Microelementy v medicine, 2015, vol. 16, no. 3, pp. 29-37. (In Russ.)] Syroeshkin A.V., Titorovich O.V., Pletneva T.V., Burdeynaya T.N. Voda, obednennaya po deyteriyu, kak ad'yuvantnoe sredstvo pri lechenii onkologicheskih zabolevaniy. Mikroelementy v medicine, 2015, t. 16, № 3, s. 29-37. [Syroeshkin A.V., Titorovich O.V., Pletneva T.V., Byrdejnaya T.N. Water depleted of deuterium as aduvant remedy for cancer therapy. Microelementy v medicine, 2015, vol. 16, no. 3, pp. 29-37. (In Russ.)] Самков А.А., Джимак С.С., Барышев М.Г. [и др.] Влияние изотопного состава воды на продукцию биомассы Rhodococcus erythropolis, Биофизика, 2015, т. 60, вып.1, с. 136-142. [Samkov A.A., Dzhimak C.C., Baryshev M.G. [et al.] The influence of water isotope content on the production of biomass Rhodococcus erythropolis, Biophysics, 2015, vol. 60, no. 1, pp. 136-142. (In Russ.)] Samkov A.A., Dzhimak S.S., Baryshev M.G. [i dr.] Vliyanie izotopnogo sostava vody na produkciyu biomassy Rhodococcus erythropolis, Biofizika, 2015, t. 60, vyp.1, s. 136-142. [Samkov A.A., Dzhimak C.C., Baryshev M.G. [et al.] The influence of water isotope content on the production of biomass Rhodococcus erythropolis, Biophysics, 2015, vol. 60, no. 1, pp. 136-142. (In Russ.)] Strekalova T., Evans M., Chernopiatko A. [et al.] Deuterium content of water increases depression susceptibility. The potential role of a serotonin-related mechanism. Behavioural Brain Research, 2015, vol. 277, pp. 237-244. Strekalova T., Evans M., Chernopiatko A. [et al.] Deuterium content of water increases depression susceptibility. The potential role of a serotonin-related mechanism. Behavioural Brain Research, 2015, vol. 277, pp. 237-244. Киркина А.А., Лобышев В.И., Лопина О.Д. [и др.] Изотопные эффекты малых концентраций дейтерия воды в биологических системах. Биофизика, 2014, т. 59, вып. 2, с. 399-407. [Kirkina A.A., Lobyshev V.I., Lopina O.D., Doronin Yu.K., Burdeinaya T.N., Chernopyatko A.S. Isotopic effects of low concentration of deuterium in water on biological systems. Biophysics, 2014, vol. 59, no. 2, pp. 399-407. (In Russ.)] Kirkina A.A., Lobyshev V.I., Lopina O.D. [i dr.] Izotopnye effekty malyh koncentraciy deyteriya vody v biologicheskih sistemah. Biofizika, 2014, t. 59, vyp. 2, s. 399-407. [Kirkina A.A., Lobyshev V.I., Lopina O.D., Doronin Yu.K., Burdeinaya T.N., Chernopyatko A.S. Isotopic effects of low concentration of deuterium in water on biological systems. Biophysics, 2014, vol. 59, no. 2, pp. 399-407. (In Russ.)]