Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54333 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ BIOLOGICAL EFFECTS OF POLYSACCHARIDES SIGNALING БИОЛОГИЧЕСКИЕ ЭФФЕКТЫ СИГНАЛИНГА ПОЛИСАХАРИДОВ Генералов Е А Generalov E A generals1179@gmail.com Яковенко Л В Yakovenko L V yakovenko.lv@physics.msu.ru Институт молекулярной биологии им. В.А. Энгельгардта ru Engelhardt Institute of Molecular Biology, Russian Academy of Sciences ru Московский государственный университет имени М.В. Ломоносова ru M.V. Lomonosov Moscow State University ru 25 09 2018 25 09 2018 3 3 588 597 20 09 2018 20 09 2018 https://rusjbpc.ru/en/nauka/article/54333/view

В статье представлен обзор основных полисахаридных рецепторов - SR, CTLR, TLR, CR, NLR, LacCer. Описаны некоторые биологические активности полисахаридов, преимущественно - иммунологические, противоопухолевые, апоптотические, а также некоторые другие. Обсуждается роль рецепторов и моносахаридных последовательностей полисахаридов в регуляции иммунного ответа. Описаны возможные типы сигналинга и роль полисахаридов в нем. Рассмотрена возможность формирования метастабильных состояний клетки, возникающие за счет возникновения разнонаправленных внутриклеточных сигнальных каскадов при взаимодействии рецепторов и комплексных полисахаридных лигандов. Предполагается, что клетка, находящаяся в особом состоянии - бифуркационном, способна «совершать выбор» между различными типами ответов: апоптоз, пролиферация, арест клеточного цикла и другими. Приведены примеры активации различных сигнальных путей под действием полисахаридов, в том числе - возможности перехода трансформированных клеток в бифуркационное состояние.

This article provides an overview of the main polysaccharide receptors - SR, CTLR, TLR, CR, NLR, LacCer. Some biological activities of polysaccharides, mainly immunological, antitumor, apoptotic, and some others also are described. The role of receptors and monosaccharide sequences of polysaccharides in the regulation of the immune response is discussed. Possible types of signaling and the role of polysaccharides in it are described. The possibility of formation of metastable states of the cell arising due to the appearance of multidirectional intracellular signaling cascades in the interaction of receptors and complex polysaccharide ligands is considered. It is assumed that a cell in a special state - a bifurcation one - is capable of "making a choice" between different types of responses: apoptosis, proliferation, cell cycle arrest, and others. Examples are given, including the possibility of transition of transformed cells into a bifurcation state in response to polysaccharide introduction into cell cultures.

 полисахариды гликаны бифуркационное состояние сигналинг рецепторы polysaccharides glycans bifurcation state signaling receptors

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