Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54346 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ SOME PHYSICOCHEMICAL PROPERTIES OF AMINO ACID IONIC LIQUIDS BASED ON ALKYLMETHYLIMIDAZOLIUM SOME PHYSICOCHEMICAL PROPERTIES OF AMINO ACID IONIC LIQUIDS BASED ON ALKYLMETHYLIMIDAZOLIUM Alopina E V Alopina E V alopina@mail.ru Smirnova N A Smirnova N A Kuznetsov O Yu Kuznetsov O Yu St. Petersburg State University ru St. Petersburg State University ru St. Petersburg State University ru St. Petersburg State University ru Ivanovo State Medical Academy «Roszdrava» ru Ivanovo State Medical Academy «Roszdrava» ru 25 09 2018 25 09 2018 3 3 669 672 20 09 2018 20 09 2018 https://rusjbpc.ru/en/nauka/article/54346/view

A modification of synthesis of amino acid ionic liquids (AAILs) based on 1-alkyl-3-methylimidazolium cation and L-Serinate anion [Cnmim][Ser] (n = 8, 10, 12) was developed. The structures of the AAILs based on serinate were confirmed by 1H NMR and 13C NMR spectroscopies. The electrical conductivity in aqueous mixtures of ionic liquids from the family 1-alkyl-3-methylimidazolium serinate [Cnmim][Ser] (n = 8, 10, 12) at 298.15 K were measured. The results of the electrical conductivity study clearly show that the general features of micellar aggregation of relatively long-chain imidazolium IL are analogous to those in the case of traditional surfactants. Critical micelle concentrations (cmc) of AAILs, degree of counterion binding ( β ), standard Gibbs energy of micellization (Δ G °m) for them were estimated from the experimental data. The dependences of the cmc, β and Δ G °m, on the length of the alkyl chain of the cations were discussed. These compounds were initially screened for biology activity by a simple zone of inhibition study against Staphylococcus aureus ATCC 5638 (gram-positive bacteria), Escherichia coli ATCC 25922 (gram-negative bacteria) and Candida albicans ATCC 885653 (fungus). The data obtained have shown that among AAILS the [C10mim][Ser] is more effective against this bacteria.

A modification of synthesis of amino acid ionic liquids (AAILs) based on 1-alkyl-3-methylimidazolium cation and L-Serinate anion [Cnmim][Ser] (n = 8, 10, 12) was developed. The structures of the AAILs based on serinate were confirmed by 1H NMR and 13C NMR spectroscopies. The electrical conductivity in aqueous mixtures of ionic liquids from the family 1-alkyl-3-methylimidazolium serinate [Cnmim][Ser] (n = 8, 10, 12) at 298.15 K were measured. The results of the electrical conductivity study clearly show that the general features of micellar aggregation of relatively long-chain imidazolium IL are analogous to those in the case of traditional surfactants. Critical micelle concentrations (cmc) of AAILs, degree of counterion binding ( β ), standard Gibbs energy of micellization (Δ G °m) for them were estimated from the experimental data. The dependences of the cmc, β and Δ G °m, on the length of the alkyl chain of the cations were discussed. These compounds were initially screened for biology activity by a simple zone of inhibition study against Staphylococcus aureus ATCC 5638 (gram-positive bacteria), Escherichia coli ATCC 25922 (gram-negative bacteria) and Candida albicans ATCC 885653 (fungus). The data obtained have shown that among AAILS the [C10mim][Ser] is more effective against this bacteria.

 amino acid ionic liquid 1-alkyl-3-methylimidazolium cation electrical conductivity micellization antibacterial effect amino acid ionic liquid 1-alkyl-3-methylimidazolium cation electrical conductivity micellization antibacterial effect

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