Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54422 Моделирование в биофизике Modelling in biophycis Моделирование в биофизике COMPUTER SIMULATION OF THE DNA DAMAGE FORMATION IN NEURAL CELLS UNDER EXPOSURE TO HEAVY CHARGED PARTICLES КОМПЬЮТЕРНОЕ МОДЕЛИРОВАНИЕ ФОРМИРОВАНИЯ ПОВРЕЖДЕНИЙ ДНК В НЕРВНЫХ КЛЕТКАХ ПРИ ВОЗДЕЙСТВИИ ТЯЖЕЛЫХ ЗАРЯЖЕННЫХ ЧАСТИЦ Батмунх М Batmunkh M batmunkh@jinr.ru Баярчимэг Л Bayarchimeg L Бугай А Н Bugay A N Лхагва О Lkhagva O Объединенный институт ядерных исследований ru Joint Institute for Nuclear Research ru Объединенный институт ядерных исследований ru Joint Institute for Nuclear Research ru Объединенный институт ядерных исследований ru Joint Institute for Nuclear Research ru Национальный университет Монголии ru National University of Mongolia ru 25 06 2019 25 06 2019 4 2 214 219 20 06 2019 20 06 2019 https://rusjbpc.ru/en/nauka/article/54422/view

В данной работе исследовано прохождение треков заряженных частиц через различные области гиппокампа крыс, который включал основные типы клеток различной морфологии. Для каждой модели нейрона смоделированы клеточное тело (сома), содержащее ядерную ДНК, аксон и дендриты, с распределенными на них шипиками и синаптическими рецепторами. С использованием метода Монте-Карло в пакете Geant4 моделировались физико-химические процессы в нейронах гиппокампа и образуемых ими нейронных сетях при облучении заряженными частицами в широком диапазоне линейной передачи энергии (ЛПЭ). Также проведен расчет формирования молекулярных повреждений различной природы в чувствительных структурах нервных клеток с учетом процессов радиолиза воды после радиационного поражения. Предсказано, что выход кластерных однонитевых разрывов ДНК, включающих повреждения оснований, максимален при значениях ЛПЭ в пределах 20-50 кэВ/мкм. Максимальный выход двунитевых разрывов ДНК на единицу поглощенной дозы наблюдается при значениях ЛПЭ в пределах 100-200 кэВ/мкм, а наибольшая часть кластерных двунитевых разрывов ДНК, включающих повреждения оснований, реализуется в области ЛПЭ около 300 кэВ/мкм. Полученные результаты находятся в согласии с известными экспериментальными данными.

In this work, we simulated the passage of charged particle tracks through various regions of the hippocampus of rats, which included the main cell types of various morphology. For each model of the neuron we modeled a cellular body (soma) with nuclear DNA, axon and dendrites, with spines and synaptic receptors distributed on them. With the use of the Geant4 Monte-Carlo method we simulated the physicochemical processes in the hippocampal neurons and the neural networks formed by them under irradiation with charged particles in a wide range of linear energy transfer (LET). The calculation of the formation of molecular damage of various types in the sensitive structures of nerve cells taking into account the processes of water radiolysis after radiation exposure was also carried out. It is predicted that the yield of cluster single-stranded DNA breaks, including base damage, has maximum at LET values in the range of 20-50 keV/μm. The maximum yield of double-stranded DNA breaks per unit of absorbed dose is observed at LET values within 100-200 keV/μm, and the largest yield of cluster double-stranded DNA breaks, including base damage, occurs in the area of LET around 300 keV/μm. The results obtained are in agreement with the published experimental data.

 нейроны трек заряженных частиц кластерное повреждение ДНК ОБЭ neurons charged particle track clustered DNA damage RBE

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