Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54429 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ INSTRUMENTAL AND METHODOLOGICAL DEVELOPMENTS FOR THE STUDY OF BIOLOGICAL STRUCTURES USING SYNCHROTRON RADIATION ИНСТРУМЕНТАЛЬНО-МЕТОДИЧЕСКИЕ РАЗРАБОТКИ ДЛЯ ИССЛЕДОВАНИЯ БИОЛОГИЧЕСКИХ СТРУКТУР С ИСПОЛЬЗОВАНИЕМ СИНХРОТРОННОГО ИЗЛУЧЕНИЯ Корнеев В Н Korneev V N kvn_40@mail.ru Шлектарёв В А Shlektarev V A Забелин А В Zabelin A V Ланина Н Ф Lanina N F Толочко Б П Tolochko B P Вазина А А Vazina A A Институт биофизики клетки РАН - обособленное подразделение ФГБУН «ФИЦ «Пущинский научный центр биологических исследований РАН» ru Institute of cell biophysics, FRC PSCBR of RAS ru Институт теоретической и экспериментальной биофизики РАН ru Institute of theoretical and experimental biophysics of RAS ru Национальный исследовательский центр «Курчатовский институт» ru National research center “Kurchatov Institute” ru Институт теоретической и экспериментальной биофизики РАН ru Institute of theoretical and experimental biophysics of RAS ru Институт ядерной физики им. Г.И. Будкера СО РАН ru Budker Institute of nuclear physics, SB of RAS ru Институт теоретической и экспериментальной биофизики РАН ru Institute of theoretical and experimental biophysics of RAS ru 25 06 2019 25 06 2019 4 2 259 269 20 06 2019 20 06 2019 https://rusjbpc.ru/en/nauka/article/54429/view

Рассмотрены основные компоненты инструментальных и методических разработок для исследования биологических тканей методами структурной биологии с использованием синхротронного излучения (СИ) из накопительных колец ВЭПП-3 и Сибирь-2 в Московском и Сибирском центрах коллективного пользования. Наша цель состоит в изучении механизмов структурно-функциональной устойчивости нативных и трансформированных тканей человека и животных при различных физико-химических воздействиях. Представлены возможности созданных аппаратуры и методов, а также экспериментальные данные по исследованию биологических полимеров с различной степенью упорядоченности в молекулярной и наномасштабной шкале.

The major elements involved in instrumental and methodical developments for biological tissue studying by means the structural biology methods based on using synchrotron radiation (SR) from VEPP-3 and Siberia-2 storage rings from two Russian centres of collective using - in the Siberian and Moscow regions are considered. Our basic concern is to study mechanisms of structural and functional stability of native and transformed human and animal tissues under various physicochemical influences. Possibilities of produced equipment and methods, as well as the experimental data on biological polymers having different degrees of order at the molecular or nanoscale level are presented.

 синхротронное излучение система первичных коллиматоров рентгеновская дифракция с высоким временным разрешением synchrotron radiation system of primary collimators high time-resolved X-ray diffraction

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