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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Russian Journal of Biological Physics and Chemisrty</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Russian Journal of Biological Physics and Chemisrty</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2499-9962</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">54444</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>Моделирование в биофизике</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>Modelling in biophycis</subject>
    </subj-group>
    <subj-group>
     <subject>Моделирование в биофизике</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">DETERMINED NATURAL SELECTION MECHANISMS LIKE A PERCOLATION GRID</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ДЕТЕРМИНИРОВАННЫЕ МЕХАНИЗМЫ ЕСТЕСТВЕННОГО ОТБОРА КАК ПЕРКОЛЯЦИОННОЙ РЕШЕТКИ</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Гараева</surname>
       <given-names>А Я</given-names>
      </name>
      <name xml:lang="en">
       <surname>Garaeva</surname>
       <given-names>A Y</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Сидорова</surname>
       <given-names>А Э</given-names>
      </name>
      <name xml:lang="en">
       <surname>Sidorova</surname>
       <given-names>A E</given-names>
      </name>
     </name-alternatives>
     <email>sky314bone@mail.ru</email>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Твердислов</surname>
       <given-names>В А</given-names>
      </name>
      <name xml:lang="en">
       <surname>Tverdislov</surname>
       <given-names>V A</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Московский государственный университет им. М.В. Ломоносова</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">Lomonosov Moscow State University</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Московский государственный университет им. М.В. Ломоносова</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">Lomonosov Moscow State University</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">Московский государственный университет им. М.В. Ломоносова</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">Lomonosov Moscow State University</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2019-09-25T20:22:29+03:00">
    <day>25</day>
    <month>09</month>
    <year>2019</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2019-09-25T20:22:29+03:00">
    <day>25</day>
    <month>09</month>
    <year>2019</year>
   </pub-date>
   <volume>4</volume>
   <issue>3</issue>
   <fpage>360</fpage>
   <lpage>363</lpage>
   <history>
    <date date-type="received" iso-8601-date="2019-09-20T20:22:29+03:00">
     <day>20</day>
     <month>09</month>
     <year>2019</year>
    </date>
    <date date-type="accepted" iso-8601-date="2019-09-20T20:22:29+03:00">
     <day>20</day>
     <month>09</month>
     <year>2019</year>
    </date>
   </history>
   <self-uri xlink:href="https://rusjbpc.ru/en/nauka/article/54444/view">https://rusjbpc.ru/en/nauka/article/54444/view</self-uri>
   <abstract xml:lang="ru">
    <p>Системно изложена роль естественного отбора в биологической эволюции, отражающая современные биологические концепции. Предложен и разработан новый подход к теоретическому обобщению и математическому описанию этой ключевой проблемы биологии, основанный на представлениях о физическом явлении «протекания». Естественный отбор оптимальных вариантов в эволюционном потоке мутаций рассмотрен в качестве перколяционного фильтра - физического инструмента, составляющего механизм отбора. Показано, что при отсутствии дрейфа процесс закрепления мутаций определяется только детерминированными механизмами отбора, т.е. наличием в популяции поддерживающих и запрещающих мутаций и их взаимодействием с новыми мутациями.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>The role of natural selection in biological evolution, reflecting modern biological concepts, is presented systematically. A new approach to the theoretical generalization and mathematical description of this key problem of biology, based on ideas about the physical phenomenon of &quot;flow&quot;, has been proposed and developed. The natural selection of optimal variants in the evolutionary mutation flow is considered as a percolation filter - a physical tool that makes up the selection mechanism. It is shown that in the absence of drift, the process of fixing mutations is determined only by determined selection mechanisms, i.e. the presence of supporting and prohibiting mutations in the population and their interaction with new mutations.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>естественный отбор</kwd>
    <kwd>самоорганизация</kwd>
    <kwd>флуктуации</kwd>
    <kwd>бифуркации</kwd>
    <kwd>перколяции</kwd>
    <kwd>мутации</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">
            
              Prigorine. I., Stingers E. Order of the chaos. New dialogue between man and nature. Per., 1986, 432 p.
            
          </mixed-citation>
     <mixed-citation xml:lang="en">
            
              Prigorine. I., Stingers E. Order of the chaos. New dialogue between man and nature. Per., 1986, 432 p.
            
          </mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">
            
              Sidorova A.E., Tverdislov V.A. Self-Organization as the Driving Force for the Evolution of the Biosphere. MOSCOW UNIVERSITY PHYSICS BULLETIN, 2012, vol. 68, no. 5, p. 405-410
            
          </mixed-citation>
     <mixed-citation xml:lang="en">
            
              Sidorova A.E., Tverdislov V.A. Self-Organization as the Driving Force for the Evolution of the Biosphere. MOSCOW UNIVERSITY PHYSICS BULLETIN, 2012, vol. 68, no. 5, p. 405-410
            
          </mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">
            
              Daniel M. Weinreich, Nigel F. Delaney, Mark A. DePristo, Daniel L. Hartl. Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins. Science, 2006, vol. 312, pp. 111-114.
            
          </mixed-citation>
     <mixed-citation xml:lang="en">
            
              Daniel M. Weinreich, Nigel F. Delaney, Mark A. DePristo, Daniel L. Hartl. Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins. Science, 2006, vol. 312, pp. 111-114.
            
          </mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">
            
              Эфрос А.Л. Физика и геометрия беспорядка. М.: Наука, 1982, 176 с. @@[Ephros A.L. Physics and Geometry of Disorder. Moscow: Science, 1982. 176 p. (In Russ.)]
            
          </mixed-citation>
     <mixed-citation xml:lang="en">
            
              Efros A.L. Fizika i geometriya besporyadka. M.: Nauka, 1982, 176 s. @@[Ephros A.L. Physics and Geometry of Disorder. Moscow: Science, 1982. 176 p. (In Russ.)]
            
          </mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">
            
              Nei M., Imaizumi Y. Genetic structure of human populations. II. Differentiation of blood group gene frequencies among isolated populations. Heredity, 1966, no. 21, p. 183.
            
          </mixed-citation>
     <mixed-citation xml:lang="en">
            
              Nei M., Imaizumi Y. Genetic structure of human populations. II. Differentiation of blood group gene frequencies among isolated populations. Heredity, 1966, no. 21, p. 183.
            
          </mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">
            
              Crow J.F., Morton N.E. Measurement of gene frequency drift in small population. Evolution, 1955, vol. 9, p. 202.
            
          </mixed-citation>
     <mixed-citation xml:lang="en">
            
              Crow J.F., Morton N.E. Measurement of gene frequency drift in small population. Evolution, 1955, vol. 9, p. 202.
            
          </mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">
            
              Nunney L.D. Estimating the effective size of conserved populations. Conservation Biology, 1994, vol. 8, p. 175.
            
          </mixed-citation>
     <mixed-citation xml:lang="en">
            
              Nunney L.D. Estimating the effective size of conserved populations. Conservation Biology, 1994, vol. 8, p. 175.
            
          </mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">
            
              Эбелинг B., Энгель A., Файстель P. Физика процессов эволюции. М.: Эдиториал УРСС, 2001, 211 c. @@[Ebeling B., Engel A., Feistel P. Physics of evolutionary processes. M.: Editorial URSS, 2001, 211 p. (In Russ.)]
            
          </mixed-citation>
     <mixed-citation xml:lang="en">
            
              Ebeling B., Engel' A., Faystel' P. Fizika processov evolyucii. M.: Editorial URSS, 2001, 211 c. @@[Ebeling B., Engel A., Feistel P. Physics of evolutionary processes. M.: Editorial URSS, 2001, 211 p. (In Russ.)]
            
          </mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">
            
              Grant V. Organismic evolution. University of Texas at Austin Foreword by G.G. Simpson, W.H. Freeman [et al.], San Francisco, 1977, 418 p.
            
          </mixed-citation>
     <mixed-citation xml:lang="en">
            
              Grant V. Organismic evolution. University of Texas at Austin Foreword by G.G. Simpson, W.H. Freeman [et al.], San Francisco, 1977, 418 p.
            
          </mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">
            
              Santiago E., Caballero A. Joint prediction of the effective population size and the rate of fixation of deleterious mutations. Genetics, 2016, vol. 204, no. 3, pp. 1267-1279.
            
          </mixed-citation>
     <mixed-citation xml:lang="en">
            
              Santiago E., Caballero A. Joint prediction of the effective population size and the rate of fixation of deleterious mutations. Genetics, 2016, vol. 204, no. 3, pp. 1267-1279.
            
          </mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
