Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54475 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ PECULIARITIES OF CAFFEINE AND CAFFEINE SODIUM BENZOATE AQUEOUS SOLUTION IN PRESENCE OF FULLERENE C60 PECULIARITIES OF CAFFEINE AND CAFFEINE SODIUM BENZOATE AQUEOUS SOLUTION IN PRESENCE OF FULLERENE C60 Golovchenko I V Golovchenko I V IVGolovchenko@sevsu.ru Rogova O V Rogova O V Zav’yalova O S Zav’yalova O S Miroshnichenko E V Miroshnichenko E V Dovgalenko V V Dovgalenko V V Sevastopol State University ru Sevastopol State University ru Sevastopol State University ru Sevastopol State University ru Sevastopol State University ru Sevastopol State University ru Sevastopol State University ru Sevastopol State University ru Sevastopol State University ru Sevastopol State University ru 25 12 2019 25 12 2019 4 4 542 545 20 12 2019 20 12 2019 https://rusjbpc.ru/en/nauka/article/54475/view

Aromatic ligands behavior (caffeine and caffeine sodium benzoate) was analyzed in pure aquatic solution and in presence of fullerene C60. To investigate the influence of fullerene C60 conductomertric titrational curves were obtained. Presence of interaction was confirmed by difference of conductivities of C60/ligand mixture and total conductivities of pure C60 and pure ligand solutions at the same concentrations used in mixture. Significant influence was noticeable with the caffeine salt. The complexation caused noticeable reduction of ligand dissociation and as a result lowering the conductivity of solution. The results of this work can find application in improving the ways of drug delivery by means of their longer preservation in their native form.

Aromatic ligands behavior (caffeine and caffeine sodium benzoate) was analyzed in pure aquatic solution and in presence of fullerene C60. To investigate the influence of fullerene C60 conductomertric titrational curves were obtained. Presence of interaction was confirmed by difference of conductivities of C60/ligand mixture and total conductivities of pure C60 and pure ligand solutions at the same concentrations used in mixture. Significant influence was noticeable with the caffeine salt. The complexation caused noticeable reduction of ligand dissociation and as a result lowering the conductivity of solution. The results of this work can find application in improving the ways of drug delivery by means of their longer preservation in their native form.

 caffeine caffeine sodium benzoate C60 fullerene molecular aggregation aquatic solutions caffeine caffeine sodium benzoate C60 fullerene molecular aggregation aquatic solutions

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