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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Russian Journal of Biological Physics and Chemisrty</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Russian Journal of Biological Physics and Chemisrty</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2499-9962</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">54568</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>Общая биофизика</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>General biophysics</subject>
    </subj-group>
    <subj-group>
     <subject>Общая биофизика</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">Hypothesis about the universal role of the auger cascade in the selection of the elemental composition and chiral dissymetry of macromolecules in living systems</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Гипотеза об универсальной роли Оже-каскада в отборе элементного состава и хиральной диссиметрии макромолекул в живых системах</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Оксенгендлер</surname>
       <given-names>Б Л</given-names>
      </name>
      <name xml:lang="en">
       <surname>Oksengendler</surname>
       <given-names>B L</given-names>
      </name>
     </name-alternatives>
     <email>oksengendlerbl@yandex.ru</email>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Тураева</surname>
       <given-names>Н Н</given-names>
      </name>
      <name xml:lang="en">
       <surname>Turaeva</surname>
       <given-names>N N</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Никифорова</surname>
       <given-names>Н Н</given-names>
      </name>
      <name xml:lang="en">
       <surname>Nikiforova</surname>
       <given-names>N N</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Минина</surname>
       <given-names>М В</given-names>
      </name>
      <name xml:lang="en">
       <surname>Minina</surname>
       <given-names>M V</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-4"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Чечулина</surname>
       <given-names>М В</given-names>
      </name>
      <name xml:lang="en">
       <surname>Chechulina</surname>
       <given-names>M V</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-5"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Искандарова</surname>
       <given-names>Ф </given-names>
      </name>
      <name xml:lang="en">
       <surname>Iskandarova</surname>
       <given-names>F </given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-6"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Институт ионно-плазменных и лазерных технологий АН РУз; Институт химии и физики полимеров АН РУз</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">Institute of Ion-Plasma and Laser Technologies, Academy of Sciences of the Republic of Uzbekistan; Institute of Polymer Chemistry and Physics, Academy of Sciences of the Republic of Uzbekistan</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Webster University, Biological Department</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">Webster University, Biological Department</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">Институт ионно-плазменных и лазерных технологий АН РУз</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">Institute of Ion-Plasma and Laser Technologies, Academy of Sciences of the Republic of Uzbekistan</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-4">
    <aff>
     <institution xml:lang="ru">ООО «NIKA PHARM»</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">OLC &quot;NIKA PHARM&quot;</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-5">
    <aff>
     <institution xml:lang="ru">ООО «NIKA PHARM»</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">OLC &quot;NIKA PHARM&quot;</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-6">
    <aff>
     <institution xml:lang="ru">Центр профилактики чумы, карантинных и особо опасных инфекций, Ферганский филиал</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">Center for the Prevention of Plague, Quarantine and Especially Dangerous Infections, Ferghana branch</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2020-12-25T20:22:29+03:00">
    <day>25</day>
    <month>12</month>
    <year>2020</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2020-12-25T20:22:29+03:00">
    <day>25</day>
    <month>12</month>
    <year>2020</year>
   </pub-date>
   <volume>5</volume>
   <issue>4</issue>
   <fpage>571</fpage>
   <lpage>579</lpage>
   <history>
    <date date-type="received" iso-8601-date="2020-12-20T20:22:29+03:00">
     <day>20</day>
     <month>12</month>
     <year>2020</year>
    </date>
    <date date-type="accepted" iso-8601-date="2020-12-20T20:22:29+03:00">
     <day>20</day>
     <month>12</month>
     <year>2020</year>
    </date>
   </history>
   <self-uri xlink:href="https://rusjbpc.ru/en/nauka/article/54568/view">https://rusjbpc.ru/en/nauka/article/54568/view</self-uri>
   <abstract xml:lang="ru">
    <p>В статье формулируется гипотеза о возможности унифицированного решения двух фундаментальных проблем биологии на основе участия в процессах эволюции Оже эффекта в качестве фильтра; это - а) неоднородность элементного состава живых систем по атомному весу (существование «лидеров» и «аутсайдеров») и б) уникальная устойчивость гомохиральных биополимеров по отношению к флуктуациям локусов противоположной симметрии. Нами показано, что оба парадоксальных явления могут быть объяснены на основе одного и того же радиационного процесса - Оже-каскада после образования вакансии в K-оболочке с последующим «кулоновским взрывом» в биополимере, чему однако препятствует электронная нейтрализация - «заливание» из остальной неповреждённой цепи биополимера. Выяснено, что большая повреждаемость связана с наличием дополнительных электронных оболочек, а также с существованием хиральной деформации биополимера. Эти два обстоятельства позволяют разрешать парадоксы как качественно, так и количественно. В частности, предложенная гипотеза объясняет существование углеродной жизни и невозможность кремниевой жизни. Кроме того, усиление деструкции от Оже-каскада по мере увеличения хирального угла выявило особые точки повреждения хирального биополимера - области контактов двух доменов с различной хиральностью, которые «вымываются» ионизирующей радиацией с повышенной вероятностью, препятствуя образованию гетерохиральных полимеров. Отмечено, что процессы, лежащие в основе этих двух парадоксов, видимо, являются хорошими примерами общей концепции «complexity». Указано, что Оже-каскад - лишь один из типов процессов подпороговой радиационной физики, которые способны объяснить целый ряд низкотемпературных явлений в биологии.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>The article formulates a hypothesis about the possibility of a unified solution of two fundamental problems of biology on the basis of participation of the Auger effect as a filter in the evolutionary processes; these are a) the inhomogeneity of the elemental composition of living systems in terms of atomic weight (the existence of “leaders” and “outsiders”) and b) the unique stability of homochiral biopolymers with respect to fluctuations of loci of opposite symmetry. We have shown that both paradoxical phenomena can be explained on the basis of one and the same radiation process - Auger cascade after the formation of a vacancy in the K-shell with the subsequent &quot;Coulomb explosion&quot; in the biopolymer, which, however, is impeded by electronic neutralization - &quot;flooding&quot; from the rest of the intact biopolymer chains. It was found that the high damageability is associated with the presence of additional electronic shells, as well as with the existence of chiral deformation of the biopolymer. These two circumstances make it possible to resolve the paradoxes both qualitatively and quantitatively. In particular, the proposed hypothesis explains the existence of carbon life and the impossibility of silicon life. In addition, the enhancement of destruction from the Auger cascade with an increase in the chiral angle revealed special points of the damage to the chiral biopolymer - the contact areas of two domains with different chiralities, which are “washed out” by ionizing radiation with an increased probability, preventing the formation of heterochiral polymers. It is noted that the processes underlying these two paradoxes are, apparently, good examples of the general concept of “complexity”. It is indicated that the Auger cascade is only one of the types of subthreshold radiation physics processes that can explain a number of low-temperature phenomena in biology.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>биополимеры</kwd>
    <kwd>парадоксы в биологии</kwd>
    <kwd>элементный состав</kwd>
    <kwd>хиральность</kwd>
    <kwd>радиация</kwd>
    <kwd>Оже-каскад</kwd>
    <kwd>«кулоновский взрыв»</kwd>
    <kwd>электронная нейтрализация</kwd>
    <kwd>«заливание»</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>biopolymers</kwd>
    <kwd>paradoxes in biology</kwd>
    <kwd>elemental composition</kwd>
    <kwd>chirality</kwd>
    <kwd>radiation</kwd>
    <kwd>Auger cascade</kwd>
    <kwd>“Coulomb explosion”</kwd>
    <kwd>electronic neutralization</kwd>
    <kwd>“flooding”</kwd>
   </kwd-group>
  </article-meta>
 </front>
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