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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Russian Journal of Biological Physics and Chemisrty</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Russian Journal of Biological Physics and Chemisrty</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2499-9962</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">54578</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY</subject>
    </subj-group>
    <subj-group>
     <subject>МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">Soliton excitation delivery and stimulation of biochemical reactions for medical purposes in living systems</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Солитонная доставка возбуждений и стимулирование биохимических реакций медицинского назначения в живых системах</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Аширметов</surname>
       <given-names>А Х</given-names>
      </name>
      <name xml:lang="en">
       <surname>Ashirmetov</surname>
       <given-names>A Kh</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Искандарова</surname>
       <given-names>Ф </given-names>
      </name>
      <name xml:lang="en">
       <surname>Iskandarova</surname>
       <given-names>F </given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Никифорова</surname>
       <given-names>Н Н</given-names>
      </name>
      <name xml:lang="en">
       <surname>Nikiforova</surname>
       <given-names>N N</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Оксенгендлер</surname>
       <given-names>Б Л</given-names>
      </name>
      <name xml:lang="en">
       <surname>Oksengendler</surname>
       <given-names>B L</given-names>
      </name>
     </name-alternatives>
     <email>oksengendlerbl@yandex.ru</email>
     <xref ref-type="aff" rid="aff-4"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Институт гематологии МЗ РУз</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">Institute of Hematology, Ministry of Health of the Republic of Uzbekistan</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Центр профилактики чумы, карантинных и особо опасных инфекций, Ферганский филиал</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">Center for the Prevention of Plague, Quarantine and Especially Dangerous Infections, Ferghana branch</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">Институт ионно-плазменных и лазерных технологий АН РУз</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">Institute of Ion-Plasma and Laser Technologies Academy of Sciences of the Republic of Uzbekistan</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-4">
    <aff>
     <institution xml:lang="ru">Институт ионно-плазменных и лазерных технологий АН РУз; Институт химии и физики полимеров АН РУз</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">Institute of Ion-Plasma and Laser Technologies Academy of Sciences of the Republic of Uzbekistan; Institute of Chemistry and Physics of Polymers, Academy of Sciences of the Republic of Uzbekistan</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2020-12-25T20:22:29+03:00">
    <day>25</day>
    <month>12</month>
    <year>2020</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2020-12-25T20:22:29+03:00">
    <day>25</day>
    <month>12</month>
    <year>2020</year>
   </pub-date>
   <volume>5</volume>
   <issue>4</issue>
   <fpage>629</fpage>
   <lpage>636</lpage>
   <history>
    <date date-type="received" iso-8601-date="2020-12-20T20:22:29+03:00">
     <day>20</day>
     <month>12</month>
     <year>2020</year>
    </date>
    <date date-type="accepted" iso-8601-date="2020-12-20T20:22:29+03:00">
     <day>20</day>
     <month>12</month>
     <year>2020</year>
    </date>
   </history>
   <self-uri xlink:href="https://rusjbpc.ru/en/nauka/article/54578/view">https://rusjbpc.ru/en/nauka/article/54578/view</self-uri>
   <abstract xml:lang="ru">
    <p>В статье изучается актуальная проблема доставки лекарств на принципиально новой основе. В противовес идеи использования наночастиц типа «core shell», где core - лечащее вещество , а shell - органическое покрытие преодолевающее физиологические барьеры, новая концепция связана с использованием особых свойств солитонных возбуждении на собственных биополимерных цепях, имеющих нониусы, «начиненные» упругими, электронно-колебательными или спиновыми возбуждениями, перемещающимися вместе с нониусом на далекие расстояния (без распада) в область зоны биохимической реакции, где возбуждение безызлучательно распадается на субстрате производя лечебный эффект. Для детальной апробации идеи в качестве солитона была использована модель краудиона Френкеля-Конторовой (1938), но с учетом, во-первых, модифицированной электронной структуры нониуса, во-вторых, его движение вдоль биополимера, в-третьих, его возможной хиральности (спиральности) и, в-четвертых, фрактальности его атомной структуры. Все эти элементы анализа, которые являются составляющими ныне набирающие силу могучей методологии Complexity (Сложность) позволили с различных сторон рассмотреть совокупность характеристик солитонного метода доставки лечебного состояния (а не лекарства!) и оценить возможности этой новой стороны наномедицины. Полученные результаты на первой, простейшей, нелинейной, одномерной модели краудиона Френкеля-Конторовой продемонстрировали новые интересные возможности сложных квазичастиц - базового понятия физики конденсированных сред.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>The article examines the actual problem of drug delivery on a fundamentally new basis. In contrast to the idea of using nanoparticles of the &quot;core shell&quot; type, where core is a healing substance, and shell is an organic coating that overcomes physiological barriers, the new concept is associated with the use of special properties of soliton excitation on biopolymer own chains, which have verniers &quot;stuffed&quot; with elastic, electronic vibrational or spin excitations moving along with the vernier over long distances (without decay) to the region of the biochemical reaction zone, where the excitation decays nonradiatively on the substrate producing a therapeutic effect. For detailed approbation of the idea, the Frenkel-Kontorova crowdion model (1938) was used as a soliton, but taking into account, first, the modified electronic structure of the vernier, second, its motion along the biopolymer, and third, its possible chirality (helicity) and fourthly, the fractality of its atomic structure. All these elements of analysis, which are components of the now gaining strength of the powerful Complexity methodology, made it possible to examine from various angles the totality of characteristics of the soliton method of delivering a therapeutic state (and not a drug!) And assess the possibilities of this new side of nanomedicine. The results obtained on the first, simplest, nonlinear, one-dimensional model of the Frenkel-Kontorova crowdion demonstrated new interesting possibilities of complex quasiparticles - the basic concept of condensed matter physics.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>физика конденсированного состояния</kwd>
    <kwd>биология</kwd>
    <kwd>медицина</kwd>
    <kwd>complexity</kwd>
    <kwd>доставка лекарств</kwd>
    <kwd>солитон</kwd>
    <kwd>краудион Френкеля-Конторовой</kwd>
    <kwd>безызлучательные переходы</kwd>
    <kwd>биохимическая реакция</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>condensed matter physics</kwd>
    <kwd>biology</kwd>
    <kwd>medicine</kwd>
    <kwd>complexity</kwd>
    <kwd>drug delivery</kwd>
    <kwd>soliton</kwd>
    <kwd>Frenkel-Kontorova crowdion</kwd>
    <kwd>nonradiative transitions</kwd>
    <kwd>biochemical reaction</kwd>
   </kwd-group>
  </article-meta>
 </front>
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