Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54582 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ Structure of composite hydrogels based on fibrin and potato galactan Структура композитных гидрогелей на основе фибрина и галактана картофеля Файзуллин Д А Faizullin D A dfaizullin@mail.ru Валиуллина Ю А Valiullina Yu A Сальников В В Salnikov V V Казанский институт биохимии и биофизики ФИЦ КазНЦ РАН ru Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS ru Казанский институт биохимии и биофизики ФИЦ КазНЦ РАН ru Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS ru Казанский институт биохимии и биофизики ФИЦ КазНЦ РАН ru Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS ru 25 12 2020 25 12 2020 5 4 659 664 20 12 2020 20 12 2020 https://rusjbpc.ru/en/nauka/article/54582/view

Композитные белок-полисахаридные гидрогели находят применение при разработке средств доставки и в регенеративной медицине благодаря дешевизне сырья, биосовместимости, малотоксичности и собственной биологической активности компонент. В работе исследована возможность получения композитных гидрогелей с использованием слабозаряженного нежелирующего полисахарида галактана картофеля и гель-образующего белка фибриногена. Результаты проведенного исследования показывают, что фибриноген связывается с галактаном, сохраняя способность к энзиматической полимеризации. Образующиеся композитные гидрогели состоят из волокон фибрина с включенными в них глобулярными частицами полисахарида и по сравнению с чистым фибрином характеризуются большей плотностью, упругостью и устойчивостью к лизису, что делает их перспективными материалами для биотехнологического и биомедицинского применения.

Composite protein-polysaccharide hydrogels are used in the development of delivery systems and in regenerative medicine for the replacement and treatment of tissues and organocellular therapy due to the cheapness of raw materials, biocompatibility, low toxicity, and intrinsic biological activity of the components. In this work, the possibility of obtaining composite hydrogels based on the weakly charged non-gelling polysaccharide galactans from potatoes and the gel-forming protein fibrinogen was investigated. The results of the study show that fibrinogen binds to galactan, preserving the ability to enzymatic polymerization. The resulting composite hydrogels consist of fibrin fibers with polysaccharide globular particles incorporated into them, and characterized by a higher density, elasticity, and resistance to lysis as compared to pure fibrin, which makes them promising for biotechnological and biomedical applications.

 белок-полисахаридные гидрогели фибрин галактан картофеля protein-polysaccharide hydrogels fibrin potato galactan Работа выполнена при финансовой поддержке совместного проекта РФФИ и Правительства Республики Татарстан № 18-415-160011

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