Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54682 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ Acidosis and Bohr effect in COVID-19 progression Ацидоз и эффект Вериго-Бора при развитии COVID-19 Лавриненко И А Lavrinenko I A lavrinenko_ia@bio.vsu.ru Семёнов Д А Semyonov D A dasem@mail.ru Лагуткин Д А Lagutkin D A lagutkin.da@phystech.edu Зайцева А Ю Zaitceva A Y anna@da-24.ru Генералов Е. А. Generalov E. A. generals1179@gmail.com Матвеева О В Matveeva O V olga.matveeva@gmail.com Егоров Е Е Yegorov Y E yegorov58@gmail.com Нечипуренко Ю Д Nechipurenko Y D nech99@mail.ru Воронежский государственный университет ru Voronezh State University ru Институт биофизики СО РАН ru Institute of Biophysics Siberian Branch RAS ru Московский физико-технический институт ru Moscow Institute of Physics and Technology ru Институт аналитического приборостроения РАН ru Institute for Analytical Instrumentation RAS ru Московский государственный университет имени М.В. Ломоносова Москва Россия Lomonosov Moscow State University Moscow Russian Federation Сендай Виралитикс ru Sendai Viralytics LLC ru Институт молекулярной биологии им. Энгельгардта РАН ru Engelhardt Institute Molecular Biology RAS ru Институт молекулярной биологии им. Энгельгардта РАН ru Engelhardt Institute Molecular Biology RAS ru 25 09 2021 25 09 2021 6 3 505 510 20 09 2021 20 09 2021 https://rusjbpc.ru/en/nauka/article/54682/view

Тяжелое течение болезни, вызванной коронавирусной инфекцией COVID-19 имеет свои особенности, выделяющие данный тип вируса среди многих инфекций. В работе развита и обоснована гипотеза о том, что одной из особенностей патогенеза тяжелых случаев COVID-19 является респираторный и метаболический ацидоз. Рассмотрено влияние гипоксии и ацидоза на развитие тяжелого течения COVID-19, описан ряд механизмов, связывающих поражающие факторы COVID-19 с ацидозом. Эти механизмы имеют триггерный, ступенчатый характер действия с выраженными положительными обратными связями. Падение сатурации крови кислородом при понижении рН крови в соответствии с известным эффектом Вериго-Бора, является характерной особенностью тяжелого течения COVID-19 и приводит к истощению компенсаторных возможностей организма по регуляции ацидоза. В условиях гипоксии и ацидоза происходит перенастройка иммунной системы, которая препятствует завершению болезни, вызывая разнонаправленные активности по стимуляции воспаления и его завершению. При этом часто происходит утяжеление болезни вместо выздоровления.

The severe course of the disease caused by the coronavirus infection COVID-19 has its own characteristics that distinguish this type of virus among many infections. The paper developed and substantiated the hypothesis that respiratory and metabolic acidosis is one of the features of the pathogenesis of severe cases of COVID-19. Several mechanisms have been described that link the damaging factors of COVID-19 with acidosis, which have a trigger, stepwise nature of action with pronounced positive feedbacks. A drop in blood oxygen saturation with a decrease in blood pH in accordance with the well-known Verigo-Bohr effect is a characteristic feature of the severe course of COVID-19 and leads to depletion of the body's compensatory capabilities to regulate acidosis. Under conditions of hypoxia and acidosis, a readjustment of the immune system occurs, which prevents the completion of the disease, causing multidirectional activities to stimulate inflammation and its completion. In this case, the disease is often aggravated instead of recovery.

 SARS-CoV-2 COVID-19 ацидоз сатурация эффект Вериго-Бора положительная обратная связь триггерные явления SARS-CoV-2 COVID-19 acidosis saturation Bohr effect positive feedback trigger phenomena Работа выполнена при поддержке Программы фундаментальных исследований государственных академий наук России на 2013-2020 годы (темы №01201363818 и № 01201363820).

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