Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 69600 10.29039/rusjbpc.2023.0598 ОБЩАЯ И МОЛЕКУЛЯРНАЯ БИОФИЗИКА GENERAL AND MOLECULAR BIOPHYSICS ОБЩАЯ И МОЛЕКУЛЯРНАЯ БИОФИЗИКА INTERPRETATION OF HOT SPOTS OF ULTRAVOLETIC MUTAGENESIS FORMED ON A LAGGING STRAND OF DOUBLE-STRANDED DNA OF THE supF GENE ИНТЕРПРЕТАЦИЯ ГОРЯЧИХ ПЯТЕН УЛЬТРАФОЛЕТОВОГО МУТАГЕНЕЗА, ОБРАЗУЮЩИХСЯ НА ЗАПАЗДЫАЮЩЕЙ НИТИ ДВУХЦЕПОЧЕЧНОЙ ДНК ГЕНА supF Гребнева Е. А. Grebneva H. A. grebneva@gmail.com Донецкий физико-технический институт им. А.А. Галкина Донецк Россия Galkin Donetsk Institute for Physics and Engineering Donetsk Russian Federation 21 05 2024 21 05 2024 8 2 125 132 13 07 2023 https://rusjbpc.ru/en/nauka/article/69600/view

В настоящее время не ясен механизм образования горячих и холодных пятен ультрафиолетового мутагенеза. Мной была разработана полимеразно-таутомерная модель механизма образования горячих и холодных пятен ультрафиолетового мутагенеза и было показано, что вероятность образования мутаций зависит от процессов распространения энергии возбуждения по молекуле ДНК. В предложенной мной полимеразно-таутомерной модели ультрафиолетового мутагенеза было показано, что мутации образуются напротив только тех цис-син циклобутановых пиримидиновых димеров, одно или оба основания в которых находятся в редких таутомерных формах. В полимеразно-таутомерной модели механизма образования горячих и холодных пятен ультрафиолетового мутагенеза мной было показано, что горячими пятнами ультрафиолетового мутагенеза являются те цис-син циклобутановые пиримидиновые димеры, на которые передается больше всего энергии возбуждения. В ряде работ мной были рассчитаны относительные вероятности образования мутаций, образовавшиеся напротив оснований ДНК, входящих в состав цис-син циклобутановых пиримидиновых димеров, появившихся при облучении двухцепочечной ДНК гена supF. В данной статье, опираясь на результаты предыдущих расчетов, интерпретируются экспериментальные данные, в которых горячими пятнами ультрафиолетового мутагенеза являются участки ДНК, состоящие из расположенных подряд трех и более пиримидиновых оснований ДНК.

At present, the mechanism of formation of hot and cold spots of ultraviolet mutagenesis is not clear. I developed a polymerase-tautomeric model of the mechanism of formation of hot and cold spots of ultraviolet mutagenesis and showed that the probability of mutation formation depends on the processes of propagation of excitation energy along the DNA molecule. In my proposed polymerase-tautomeric model of ultraviolet mutagenesis, it was shown that mutations are formed opposite only those cis-syn cyclobutane pyrimidine dimers, one or both of which are in rare tautomeric forms. In the polymerase-tautomeric model of the mechanism of formation of hot and cold spots of ultraviolet mutagenesis, I have shown that the hot spots of ultraviolet mutagenesis are those cis-syn cyclobutane pyrimidine dimers to which the most excitation energy is transferred. In a number of works, I calculated the relative probabilities of mutations formed opposite the DNA bases that are part of the cis-syn cyclobutane pyrimidine dimers that appeared upon irradiation of double-stranded DNA of the supF gene. In this article, based on the results of previous calculations, I interpret experimental data in which hot spots of ultraviolet mutagenesis are DNA regions consisting of three or more pyrimidine DNA bases arranged in a row.

 УФ-мутагенез редкие таутомерные формы оснований ДНК цис-син циклобутановые пиримидиновые димеры горячие и холодные пятна ультрафиолетового мутагенеза передача энергии возбуждения по молекуле ДНК синглетные уровни оснований ДНК триплетные уровни оснований ДНК UV mutagenesis rare tautomeric forms of DNA bases cis-syn cyclobutane pyrimidine dimers hot and cold spots of ultraviolet mutagenesis excitation energy transfer along the DNA molecule singlet levels of DNA bases triplet levels of DNA bases

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