Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 83716 10.29039/rusjbpc.2023.0650 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ SAFETY OF CARBON NANOCARRIERS IN BIOMEDICAL APPLICATIONS: BIOCOMPATIBILITY OF GRAPHENE AND ITS DERIVATIVES БЕЗОПАСНОСТЬ УГЛЕРОДНЫХ НАНОНОСИТЕЛЕЙ В БИОМЕДИЦИНСКИХ ПРИЛОЖЕНИЯХ: БИОСОВМЕСТИМОСТЬ ГРАФЕНА И ЕГО ПРОИЗВОДНЫХ Ботин А. С. Botin A. S. botin-as@rudn.ru Ризк М.Г.Х. Rizk M.G.H. Попова Т. С. Popova T. S. Кордова А. В. Cordova A. V. Российский университет дружбы народов им. Патриса Лумумбы Москва Россия RUDN University Moscow Russian Federation НИИ Скорой помощи им. Н.В. Склифосовского ДЗМ Москва Россия N.V. Sklifosovsky Institute of Emergency Medicine Moscow Russian Federation Российский университет дружбы народов им. Патриса Лумумбы Москва Россия RUDN University Moscow Russian Federation НИИ Скорой помощи им. Н.В. Склифосовского ДЗМ Москва Россия N.V. Sklifosovsky Institute of Emergency Medicine Moscow Russian Federation Российский университет дружбы народов им. Патриса Лумумбы Москва Россия RUDN University Moscow Russian Federation 06 06 2024 06 06 2024 8 4 486 492 29 08 2023 https://rusjbpc.ru/en/nauka/article/83716/view

В статье рассматривается один из важнейших факторов, позволяющих определить возможность широкого и безопасного применения графеновых нанообъектов в современной биомедицине - это фактор биосовместимости, а именно взаимодействие графенсодержащего вещества с заданным участком организма, который реализуется на разных масштабах и на разных уровнях организации живой материи. Графен и его производные продемонстрировали исключительные свойства и потенциал для различных применений. Хотя производные графена, такие как оксид графена (GO), восстановленный оксид графена (rGO), немногослойный графен (FLG) и многослойный графен (MLG), обладают свойствами, сходными со свойствами графена, необходимы дополнительные исследования для решения проблемы масштабируемости и экономической эффективности для практических применений. В тканевой инженерии материалы на основе графена показали себя многообещающими в качестве каркасов, биосенсоров и систем доставки лекарств, но оптимизация стратегий биосовместимости и функционализации имеет решающее значение для безопасного и эффективного использования. Эта работа представляет собой попытку лучше понять сложные взаимодействия между графеном и биологическими системами, включая клетки, ткани и органы, что необходимо для будущих исследований и расширения использования графена в биомедицинских приложениях.

The article considers one of the most important factors allowing to determine the possibility of wide and safe use of graphene nanoobjects in modern biomedicine - this is the biocompatibility factor, namely, the interaction of a graphene-containing substance with a given part of the body, which is realized at different scales and at different levels of organization of living matter. Graphene and its derivatives have shown exceptional properties and potential for various applications. While graphene derivatives as graphene-oxide (GO), reduced graphene-oxide (rGO), few-layers graphene (FLG), and multi-layers graphene (MLG) exhibit similar properties to graphene, more research is needed to address scalability and cost-effectiveness for practical applications. In tissue engineering, graphene-based materials have shown promise in scaffolds, biosensors, and drug delivery systems, but optimizing biocompatibility and functionalization strategies are crucial for safe and effective use. This work is a try to better understanding the complex interactions between graphene and biological systems, including cells, tissues, and organs, which is necessary for future research and expanding the use of graphene in biomedical applications.

 графен биосовместимость функционализация биомедицинские приложения graphene biocompatibility functionalization biomedical applications

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