CARBON NANOCOMPOSITES IN MEDICINE: GRAPHENE AND POLYGRAPHENE AS POSSIBLE DRUG DELIVERY VEHICLE FOR INTESTINAL ONCOLOGY

A. Botin; D. Mashal; T. Popova; M.G.H. Rizk; A. Cordova

doi:10.29039/rusjbpc.2023.0649

CARBON NANOCOMPOSITES IN MEDICINE: GRAPHENE AND POLYGRAPHENE AS POSSIBLE DRUG DELIVERY VEHICLE FOR INTESTINAL ONCOLOGY

Published in Russian Journal of Biological Physics and Chemisrty · Pages 477–485 · Rubric: MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY

DOI: https://doi.org/10.29039/rusjbpc.2023.0649

Received: 26.08.2023 Accepted: 06.06.2024 Published: 06.06.2024

Authors

A. Botin

D. Mashal

T. Popova

M.G.H. Rizk

A. Cordova

A. Botin

RUDN University Russian Federation · Moscow

N.V. Sklifosovsky Institute of Emergency Medicine Russian Federation · Moscow

D. Mashal

RUDN University Russian Federation · Moscow

T. Popova

N.V. Sklifosovsky Institute of Emergency Medicine Russian Federation · Moscow

M.G.H. Rizk

RUDN University Russian Federation · Moscow

A. Cordova

RUDN University Russian Federation · Moscow

ABSTRACT

The paper considers one of the most important directions in modern pharmacology - targeted delivery of medicines, namely the directed transport of medicinal substance to given area of body, which is realized with help of carriers, which, as a rule, have sizes of tens or hundreds of nanometers, different nature and chemical structure. The delivery of antitumor drugs using nanoparticles is being discussed. Immobilization of drugs on nanocarriers makes it possible to increase their bioavailability. Various graphene derivatives - graphene oxide (GO) and reduced graphene oxide (RGO) - are being tested as carriers for drug delivery. There are several approaches for targeted drug delivery in oncology. The first, simple one is the attachment of both low– and high-molecular preparation to the surface of the carrier directly. The drug doxorubicin is firmly bound to surface of graphene oxide and is released only in acidic environment of tumor. The second, more complex method is to attach to surface of carrier not only active substance, but also guiding molecules - ligands. Sometimes ligand itself can be a drug at the same time. Polygraphene (PG) is an original modified analogue of thermally split graphite, obtained in the form of new form of expanded graphite, after repeated chemical modification and thermal activation, it is reduced to the characteristics of a layered material with stacks of carbon monolayers of smaller multiplicity (from 5 to 50), up to single sheets of graphene. The results of tests of PG as an effective basis for the immobilization of enzymes are presented, in particular, on the example of antitumor enzyme L-lysine-α-oxidase. These data indicate prospects of possible biomedical use of PG in oncology, namely, in treatment of intestinal cancer. Modified forms of graphene and polygraphene should be considered as new carrier of drugs.

KEYWORDS

graphene, polygraphene, drug delivery, intestinal oncology

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This work is licensed under Creative Commons Attribution 4.0 International Creative Commons

GOST

Botin A. S., Mashal D. A., Popova T. S., Rizk M., Cordova A. V. CARBON NANOCOMPOSITES IN MEDICINE: GRAPHENE AND POLYGRAPHENE AS POSSIBLE DRUG DELIVERY VEHICLE FOR INTESTINAL ONCOLOGY // . 2024. pp. 477-485. DOI: https://doi.org/10.29039/rusjbpc.2023.0649. (Date of access 20.08.2026).

MLA

A. Botin, Mashal D. A., Popova T. S., Rizk M., Cordova A. V.. "CARBON NANOCOMPOSITES IN MEDICINE: GRAPHENE AND POLYGRAPHENE AS POSSIBLE DRUG DELIVERY VEHICLE FOR INTESTINAL ONCOLOGY." (2024): 477-485. DOI: https://doi.org/10.29039/rusjbpc.2023.0649.

APA

Botin A. S., Mashal D. A., Popova T. S., Rizk M., Cordova A. V. (2024). CARBON NANOCOMPOSITES IN MEDICINE: GRAPHENE AND POLYGRAPHENE AS POSSIBLE DRUG DELIVERY VEHICLE FOR INTESTINAL ONCOLOGY. , 477-485. https://doi.org/10.29039/rusjbpc.2023.0649

Chicago

A. Botin, Mashal D. A., Popova T. S., Rizk M., Cordova A. V.. "CARBON NANOCOMPOSITES IN MEDICINE: GRAPHENE AND POLYGRAPHENE AS POSSIBLE DRUG DELIVERY VEHICLE FOR INTESTINAL ONCOLOGY." , no. (2024): 477-485. https://doi.org/10.29039/rusjbpc.2023.0649.

WIKI

{{cite journal | author = Botin A. S., Mashal D. A., Popova T. S., Rizk M., Cordova A. V. | title = CARBON NANOCOMPOSITES IN MEDICINE: GRAPHENE AND POLYGRAPHENE AS POSSIBLE DRUG DELIVERY VEHICLE FOR INTESTINAL ONCOLOGY | journal = | year = 2024 | pages = 477-485 | doi = 10.29039/rusjbpc.2023.0649 }}

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