Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54097 БИООРГАНИЧЕСКАЯ, БИОФИЗИЧЕСКАЯ И МЕДИЦИНСКАЯ ХИМИЯ BIOORGANIC, BIOPHYSICAL AND MEDICINAL CHEMISTRY БИООРГАНИЧЕСКАЯ, БИОФИЗИЧЕСКАЯ И МЕДИЦИНСКАЯ ХИМИЯ EFFECT OF OREGANO ESSENTIAL OIL ON THE FATTY ACID COMPOSITION IN AGING MOUSE BRAIN ВЛИЯНИЕ ЭФИРНОГО МАСЛА ОРЕГАНО НА СОСТАВ ЖИРНЫХ КИСЛОТ В МОЗГЕ СТАРЕЮЩИХ МЫШЕЙ Мишарина Т А Misharina T A tmish@rambler.ru Теренина М Б Terenina M B Крикунова Н И Krikunova N I Фаткуллина Л Д Fatkullina L D Бурлакова Е Б Burlakova E B ФГБУН Институт биохимической физики им. Н.М. Эмануэля РАН ru Emanuel Institute of Biochemical Physics of Russian Academy of Sciences ru ФГБУН Институт биохимической физики им. Н.М. Эмануэля РАН ru Emanuel Institute of Biochemical Physics of Russian Academy of Sciences ru ФГБУН Институт биохимической физики им. Н.М. Эмануэля РАН ru Emanuel Institute of Biochemical Physics of Russian Academy of Sciences ru ФГБУН Институт биохимической физики им. Н.М. Эмануэля РАН ru Emanuel Institute of Biochemical Physics of Russian Academy of Sciences ru ФГБУН Институт биохимической физики им. Н.М. Эмануэля РАН ru Emanuel Institute of Biochemical Physics of Russian Academy of Sciences ru 25 12 2016 25 12 2016 1 2 185 189 20 12 2016 20 12 2016 https://rusjbpc.ru/en/nauka/article/54097/view

Методом капиллярной газожидкостной хроматографии и хромато-масс-спектрометрии изучено изменение состава жирных кислот в липидах мозга мышей линии Balb с увеличением возраста от 1 до 24 месяцев. Найдено, что в процессе старения мышей доля насыщенных кислот монотонно снижалась, мононенасыщенных увеличивалась, полиненасыщенных достигала максимума в 4 мес., затем снижалась. При ежедневном приеме малых доз эфирного масла орегано в мозге мышей в возрасте 24 мес. сохранялся высоким уровень полиненасыщенных жирных кислот, в том числе докозагексаеновой кислоты, которая отвечает за сохранение и поддержание ряда жизненно важных функций мозга. Обнаружено, что средняя продолжительность жизни мышей, принимающих эфирное масло, увеличивалась на 120 дней.

Changes of fatty acids composition in the brain lipids of intact mice of Balb line with age increasing from 1 to 24 mounts were studied by capillary gas-liquid and gas chromatography-mass spectrometry. It was found, that occurred with age the content of saturated acids was decreased monotonically, but the content monounsaturated acids was increased, and the content of polyunsaturated acids reached a maximum at 4 months and then decreased. As a result of long-term administration of low doses of oregano essential oil, the level of polyunsaturated fatty acids, (including docosahexaenoic acid, which is responsible for the preservation and maintenance of a number of vital functions of the brain) remained high. The average lifespan of mice, that were administered with essential oil, increased to 120 days.

 жирные кислоты мозг мыши газовая хроматография fatty acids mice brain capillary gas-liquid chromatography

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