Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54111 Общая биофизика General biophysics Общая биофизика Electron microscopy of a biofilm formed in a laboratory stand Электронная микроскопия биопленки, сформированной в условиях лабораторного стенда Погорелова М А Pogorelova M A agpogorelov@rambler.ru Кузнецов А. Л. Kusnetsov A. L. Левачева М А Levacheva M A Суворов О А Suvorov O A Ипатова Л Г Ipatova L G Институт теоретической и экспериментальной биофизики РАН ru Institute of Theoretical and Experimental Biophysics, RAS ru Институт теоретической и экспериментальной биофизики РАН Пущино Россия Institute of Theoretical and Experimental Biophysics, RAS Pushchino Russian Federation Институт теоретической и экспериментальной биофизики РАН ru Institute of Theoretical and Experimental Biophysics, RAS ru Институт теоретической и экспериментальной биофизики РАН ru Institute of Theoretical and Experimental Biophysics, RAS ru Институт теоретической и экспериментальной биофизики РАН ru Institute of Theoretical and Experimental Biophysics, RAS ru 25 06 2017 25 06 2017 2 1 40 43 20 06 2017 20 06 2017 https://rusjbpc.ru/en/nauka/article/54111/view

Биопленка представляет собой сообщество разных видов, не конкурирующих микроорганизмов, которые образуют многофункциональный симбиоз сложной архитектуры. По всем признакам такую колонию следует рассматривать, как биологическую ткань, обладающую особыми свойствами. В их ряду способность к самоорганизации посредством формирования гликопротеинового матрикса, который за счет адгезии к подложке образует комфортную среду обитания. Отметим химическую агрессивность, как способ закрепления на поверхности и получения субстратов, но одновременно причина коррозии самых стойких материалов. Далее, биологическая активность, которая выражается в неконтролируемом воспроизводстве даже при гипоксии, ограниченном только доступностью ресурсов. Многослойная пространственная организация, наличие механизмов поддержания гомеостаза, способность к быстрой мутации делает биопленки устойчивыми к действию многих химических, физических или бактериологических факторов. Этим же объясняется феноменальная резистентность биопленки к антибиотикам широкого спектра действия.

Biofilm is a community of different types of non-competing microorganisms that form a multi-functional symbiosis of complex architecture. By all indications, such a colony should be regarded as a biological tissue possessing special properties. In their series, the ability to self-organization through the formation of glycoprotein matrix, which due to adhesion to the substrate forms a comfortable habitat. We note the chemical aggressiveness as a way of fixing on the surface and source of substrates, but at the same time the cause of corrosion of the most resistant materials. Next, we note the biological activity, which is expressed in uncontrolled reproduction, even under hypoxia, limited only by the availability of resources. Multilayer spatial organization, the presence of mechanisms for maintaining homeostasis, makes biofilms resistant to many chemical, physical or bacteriological factors, including disinfection. This explains the phenomenal resistance of biofilms to broad-spectrum antibiotics.

 реактор биопленок полимерный матрикс 3D микробиологический симбиоз сканирующая электронная микроскопия электрохимически активированная вода flow cell biofilm reactor polymeric matrix 3D bacterial communities scanning electron microscopy electrochemically activated water

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