Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54209 БИООРГАНИЧЕСКАЯ, БИОФИЗИЧЕСКАЯ И МЕДИЦИНСКАЯ ХИМИЯ BIOORGANIC, BIOPHYSICAL AND MEDICINAL CHEMISTRY БИООРГАНИЧЕСКАЯ, БИОФИЗИЧЕСКАЯ И МЕДИЦИНСКАЯ ХИМИЯ Effects of microwawe radiation on dehydrogenase activity in experimental tumor cells Динамика активности дегидрогеназ в клетках экспериментальной опухоли после воздействия электромагнитного сверхвысокочастотного излучения Крюкова О В Kryukova O V marta913@mail.ru Пьянков В Ф Pyankov V F Федеральный исследовательский центр "Красноярский научный центр Сибирского отделения РАН" ru Federal Research Center «Krasnoyarsk Science Center» of the Siberian Branch of the Russian Academy of Sciences ru Федеральный исследовательский центр "Красноярский научный центр Сибирского отделения РАН"; Сибирский федеральный университет ru Federal Research Center «Krasnoyarsk Science Center» of the Siberian Branch of the Russian Academy of Sciences; Siberian Federal University ru 25 06 2017 25 06 2017 2 1 426 430 20 06 2017 20 06 2017 https://rusjbpc.ru/en/nauka/article/54209/view

В работе проведена оценка изменения активности ферментов (Г6ФДГ, ГР, ЛДГ, обр.ЛДГ, НАДМДГ) в клетках асцитной карциномы Эрлиха на разных стадиях роста опухоли после воздействия сверхвысокочастотного электромагнитного излучения. Показано, что изменение активности ферментов зависит не только от оказываемого воздействия, но от особенностей метаболизма опухолевых клеток, которые связаны с переходом опухоли в следующую стадию роста в организме животного. В целом наблюдаемые изменения активности ферментов свидетельствуют о рассогласовании процессов регуляции анаэробного и аэробного обменов в клетках асцитной карциномы Эрлиха под действием сверхвысокочастотного электромагнитного излучения. При этом при воздействии электромагнитного поля изменение активности Г6ФДГ и ГР носит несогласованный характер, что в свою очередь приводит к уменьшению способности клетки противостоять процессам свободно-радикального окисления макромолекул, развивающимся в результате экстремального воздействия.

The changes of the enzymes activity (G6FDH, GR, LDH, MDH) in Ehrlich ascites carcinoma cells at different stages of tumor growth after exposure to microwave radiation have been studied. It is shown that the change in the activity of enzymes depends not only on the effect of microwave radiation, but on the characteristics of the metabolism of tumor cells, which are associated with the tumor growth stage in the mice organism. The observed changes in the activity of enzymes indicate discrepancy in the regulation of anaerobic and aerobic metabolism in Ehrlich ascites carcinoma cells in the microwave radiation exposure. Under microwave radiation the changes in the activity of G6PDH and GR are inconsistent, which leads to a decrease in the cell ability to resist the processes of generation of reactive oxygen.

 дегидрогеназы активность ферментов электромагнитное излучение СВЧ-излучение сотовый телефон асцитная карцинома Эрлиха dehydrogenase enzyme activity electromagnetic radiation microwave radiation cell phone Ehrlich ascites carcinoma

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