Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54219 БИООРГАНИЧЕСКАЯ, БИОФИЗИЧЕСКАЯ И МЕДИЦИНСКАЯ ХИМИЯ BIOORGANIC, BIOPHYSICAL AND MEDICINAL CHEMISTRY БИООРГАНИЧЕСКАЯ, БИОФИЗИЧЕСКАЯ И МЕДИЦИНСКАЯ ХИМИЯ Peculiarrities of the formation and subsequent removal of the circulation immune complexes from the bloodstreem during the process of digistation Особенности формирования и последующего удаления из кровотока циркулирующих иммунных комплексов в процессе пищеварения Ланда С Б Landa S B sergey.landa@gmail.com Семенова Е В Semenova E V Филатов М В Filatov M V Петербургский институт ядерной физики им. Б.П. Константинова Национальный исследовательский центр «Курчатовский институт» ru Petersburg nuclear physics institute named by B.P.Konstantinov of National Research Centre «Kurchatov Institute» ru Петербургский институт ядерной физики им. Б.П. Константинова Национальный исследовательский центр «Курчатовский институт» ru Petersburg nuclear physics institute named by B.P.Konstantinov of National Research Centre «Kurchatov Institute» ru Петербургский институт ядерной физики им. Б.П. Константинова Национальный исследовательский центр «Курчатовский институт» ru Petersburg nuclear physics institute named by B.P.Konstantinov of National Research Centre «Kurchatov Institute» ru 25 06 2017 25 06 2017 2 1 461 467 20 06 2017 20 06 2017 https://rusjbpc.ru/en/nauka/article/54219/view

С помощью метода динамического светорассеяния мы обнаружили, что при пищеварении в крови крыс и человека образуется значительное количество иммунных комплексов. У крыс пищевые ИК практически сразу фильтруются в печени, не циркулируя с кровотоком по организму. У человека уровень пищевых иммунных комплексов в крови нарастает в течение 3.5 часов после приема пищи, затем происходит их постепенное удаление в течение 7-8 часов. При этом в период времени, когда уровень пищевых комплексов в крови достигает своего максимума, их размеры и вклад в суммарное рассеяние у различных доноров очень близки по своим значениям. Обнаружено, что в процессе пищеварения у человека изотипический состав иммуноглобулинов в ЦИК изменяется, становясь разнообразнее. Обсуждаются возможные причины и молекулярно-клеточные механизмы описанных явлений.

Using the method of dynamic light scattering, we found that a large number of immune complexes are formed in the blood of rats and humans during the digestion. In rats, food IC is almost immediately filtered in the liver, without circulating with the bloodstream through the body. In humans, the level of food immune complexes in the blood increases for 3.5 hours after ingestion, then within 7-8 hours their gradual removal takes place. At the same time, when the level of food complexes in the blood reaches its maximum, their sizes and contribution to the total scattering in different donors are very similar in their values. It was found that in the process of digestion in humans, the isotypic composition of immunoglobulins in the CIC changes and becomes more diverse. Possible causes and molecular-cellular mechanisms of the described phenomena are discussed.

 изотипы иммуноглобулинов метод динамического светорассеяния пищеварение циркулирующие иммунные комплексы isotypes of immunoglobulins dynamic light scattering method digestion circulating immune complexes

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