Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54273 ЭКОЛОГИЧЕСКАЯ БИОФИЗИКА ECOLOGICAL BIOPHYSICS ЭКОЛОГИЧЕСКАЯ БИОФИЗИКА PHYSICO-CHEMICAL AND FUNCTIONAL CHARACTERISTICS OF COMPLETE SYSTEM OF NATURAL OLIGOPEPTIDES ФИЗИКО-ХИМИЧЕСКИЕ И ФУНКЦИОНАЛЬНЫЕ ХАРАКТЕРИСТИКИ ПОЛНОЙ СИСТЕМЫ ПРИРОДНЫХ ОЛИГОПЕПТИДОВ Замятнин А А Zamyatnin A A aaz@inbi.ras.ru Институт биохимии им. А.Н. Баха; ФИЦ “Фундаментальные основы биотехнологии” РАН ru A.N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences ru 25 03 2018 25 03 2018 3 1 225 235 20 03 2018 20 03 2018 https://rusjbpc.ru/en/nauka/article/54273/view

Проведен анализ массива данных о структурах и функциях молекул природных пептидов. Рассмотрено понятие олигопептида не только с химической точки зрения, но и с точки зрения математических представлений о малых числах. Описаны общие принципы биогенеза природных олигопептидов из специализированных неспециализированных предшественников. На основании этих представлений сформулировано понятие полной системы молекул данного типа. Показано, какие физические принципы лежат в основе функциональной активности олигопептидов. В качестве примера на основании информации базы данных EROP-Moscow о структурно-функциональных характеристиках олигопептидов, обладающих нейрональной, антимикробной, гормональной и фермент-ингибирующей активностью, рассмотрен ряд математических, химических, физических и биологических особенностей совокупности природных олигопептидов. Показано существенное отличие этих веществ от полипептидных молекул белков по физико-химическим характеристикам. Эти характеристики могут быть ключевыми в понимании молекулярных механизмов действия олигопептидов, приводящих к проявлению физиологических эффектов.

An analysis of the array of data on the structures and functions of molecules of natural peptides is carried out. The concept of an oligopeptide is considered not only from a chemical point of view, but also from the point of view of mathematical notions of small numbers. General principles of biogenesis of natural oligopeptides from specialized and non-specialized precursors are described. Therefrom, the concept of a complete system of given type molecules is formulated. It is shown which physical principles underlie the functional activity of oligopeptides. As an illustration, based on the information of the EROP-Moscow database on structural and functional characteristics of oligopeptides possessing neuronal, antimicrobial, hormonal and enzyme inhibitory activity, a number of mathematical, chemical, physical and biological features of the set of natural oligopeptides have been considered. There is the substantial difference of these substances from polypeptide molecules of proteins according to their physicochemical characteristics. These characteristics may be critical for understanding the molecular mechanisms of the action of oligopeptides that lead to the development of physiological effects.

 олигопептид белок фрагмент структура функция регуляция активность биогенез база EROP-Moscow oligopeptide protein fragment structure function regulation activity biogenesis EROP-Moscow database

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