Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54307 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ RED AND GREEN RANGE OF LED IRRADIATION OF INFLUENCE ON MITOCHONDRIAL MEMBRANE POTENTIAL AND WORK OF GENETIC APPARATUS IN EARLY MICE EMBRYOS СВЕТОДИОДНОЕ ИЗЛУЧЕНИЕ КРАСНОГО И ЗЕЛЕНОГО ДИАПАЗОНОВ УВЕЛИЧИВАЕТ МИТОХОНДРИАЛЬНЫЙ ПОТЕНЦИАЛ И МОДУЛИРУЕТ РАБОТУ ГЕНЕТИЧЕСКОГО АППАРАТА РАННИХ ЭМБРИОНОВ МЫШЕЙ Чернов А С Chernov A S alexandrchernov1984@gmail.com Ковалицкая Ю А Kovalitskaya Yu A Василов Р Г Vasilov R G Национальный исследовательский центр «Курчатовский институт» ru National Research Center «Kurchatov Institute» ru Филиал Института биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН ru Branch of Shemyakin and Ovchinnikov institute of bioorganic chemistry RAS ru Национальный исследовательский центр «Курчатовский институт» ru National Research Center «Kurchatov Institute» ru 25 06 2018 25 06 2018 3 2 427 432 20 06 2018 20 06 2018 https://rusjbpc.ru/en/nauka/article/54307/view

Измерен уровень митохондриального потенциала у доимплантационных эмбрионов мыши на стадии зиготы, 2-х, 4-х и 8-ми бластомеров. Показано, что под воздействием светодиодного зеленого (λmax = 520 нм) и красного (λmax = 635 нм) света в 2-х клеточных эмбрионах происходят изменения, сопровождающиеся ростом экспрессии генов пролиферации, репарации ДНК и антиапоптотических маркеров. Зеленый свет увеличивает жизнеспособность 2-клеточных эмбрионов и приводит к увеличению митохондриального потенциала.

Level of mitochondrial potential for the preimplantation mice embryos at a zygote stage, the 2-cell, the 4-cell and 8-cell was established. Our data indicate that the green light increase viability of 2-cell embryos and contributed to increase of mitochondrial potential. Under the influence of green (λmax = 520nm) and red (λmax = 635nm) light from light-emitting diodes contributed to increase of an expression of genes of a proliferation, reparation of DNA and anti-apoptotic markers in 2-cell mice embryos.

 доимплантационные эмбрионы низкоинтенсивное световое излучение биоэлектрические сигналы митохондриальный потенциал экспрессия генов pre-implantation embryos low-intensity light radiation bioelectric signals mitochondrial potential gene expression

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