Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54358 Общая биофизика General biophysics Общая биофизика COMPLEXATION BETWEEN C60 FULLERENE AND ACRIDINE MUTAGEN ICR-191 IN AQUEOUS SOLUTION КОМПЛЕКСООБРАЗОВАНИЕ ФУЛЛЕРЕНА C60 С АКРИДИНОВЫМ МУТАГЕНОМ ICR-191 В ВОДНОМ РАСТВОРЕ Сало В А Salo V A viktoriya_salo@mail.ru Бучельников А С Buchelnikov A S Воронин Д П Voronin D P Евстигнеев М П Evstigneev M P Севастопольский государственный университет ru Sevastopol State University ru Санкт-Петербургский государственный университет ru Saint Petersburg State University ru Севастопольский государственный университет ru Sevastopol State University ru Севастопольский государственный университет ru Sevastopol State University ru 25 12 2018 25 12 2018 3 4 738 744 20 12 2018 20 12 2018 https://rusjbpc.ru/en/nauka/article/54358/view

С помощью различных физико-химических методов проведено исследование межмолекулярных взаимодействий в системе Фуллерен С60 - ICR-191. Данные спектрофотометрического титрования, динамического светорассеяния, атомно-силовой микроскопии, а также изотермальной титрационной калориметрии указывают на образование прочных нековалентных комплексов между молекулами фуллерена и мутагена. Дополнительное подтверждение этому получено с помощью методов молекулярной динамики.

Intermolecular interactions in ‘C60 fullerene - ICR-191’ system were studied by means of various physico-chemical methods. UV/Vis spectroscopy, dynamic light scattering, atomic force microscopy and isothermal titration calorimetry data indicate the formation of strong non-covalent complexes between fullerene and mutagen molecules. Additional confirmation was obtained using molecular dynamics methods.

 агрегация фуллерен C60 мутаген спектрофотометрия динамическое светорассеяние изотермальная титрационная калориметрия aggregation C60 fullerene mutagen UV/Vis spectroscopy dynamic light scattering isothermal titration calorimetry

Bakry R, Vallant R.M., Najam-ul-Haq M., Rainer M, Szabo Z., Huck C.W. [et al.] Medicinal applications of fullerenes. Int. J. Nanomed., 2007, vol. 2, pp. 639-649. Bakry R, Vallant R.M., Najam-ul-Haq M., Rainer M, Szabo Z., Huck C.W. [et al.] Medicinal applications of fullerenes. Int. J. Nanomed., 2007, vol. 2, pp. 639-649. Prylutskyy Y., Evstigneev M.P, Pashkova I.S., Wyrzykowski D., Woziwodzka A, Golunski G. [et al.] Characterization of C60 fullerene complexation with antibiotic doxorubicin, Phys. Chem. Chem. Phys., 2014, pp. 23164-23172. Prylutskyy Y., Evstigneev M.P, Pashkova I.S., Wyrzykowski D., Woziwodzka A, Golunski G. [et al.] Characterization of C60 fullerene complexation with antibiotic doxorubicin, Phys. Chem. Chem. Phys., 2014, pp. 23164-23172. Skamrova G.B., Laponogov I., Buchelnikov A.S., Shckorbatov Y.G., Prylutska S.V., Ritter U. [et al.] Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules, Eur. Biophys. J., 2014, vol. 43, pp. 265-276. Skamrova G.B., Laponogov I., Buchelnikov A.S., Shckorbatov Y.G., Prylutska S.V., Ritter U. [et al.] Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules, Eur. Biophys. J., 2014, vol. 43, pp. 265-276. Fan J., Fang G., Zeng F., Wang X., Wu Su. Water-dispersible fullerene aggregates as a targeted anticancer prodrug with both chemo- and photodynamic therapeutic actions, Small, 2013, vol. 9, pp.613-621. Fan J., Fang G., Zeng F., Wang X., Wu Su. Water-dispersible fullerene aggregates as a targeted anticancer prodrug with both chemo- and photodynamic therapeutic actions, Small, 2013, vol. 9, pp.613-621. Hughes G.A. Nanostructure-mediated drug delivery, Nanomed.: Nanotechnol.Biol. Med., 2005, vol. 1, pp. 22-30. Hughes G.A. Nanostructure-mediated drug delivery, Nanomed.: Nanotechnol.Biol. Med., 2005, vol. 1, pp. 22-30. Shershakova N., Baraboshkina E., Andreev S., Purgina D., Struchkova I., Kamyshnikov O. [et al.] Anti-inflammatory effect of fullerene C60 in a mice model of atopic dermatitis, J. Nanobiotechnol,, 2016. Shershakova N., Baraboshkina E., Andreev S., Purgina D., Struchkova I., Kamyshnikov O. [et al.] Anti-inflammatory effect of fullerene C60 in a mice model of atopic dermatitis, J. Nanobiotechnol,, 2016. Ryan J.J., Bateman H.R., Stover A., Gomez G., Norton S.K., Zhao W. [et al.] Fullerene nanomaterials inhibit the allergic response. J. Immunol., 2007, vol.179, pp. 665-672. Ryan J.J., Bateman H.R., Stover A., Gomez G., Norton S.K., Zhao W. [et al.] Fullerene nanomaterials inhibit the allergic response. J. Immunol., 2007, vol.179, pp. 665-672. Evstigneev M.P., Buchelnikov A.S., Voronin D.P., Rubin Y.V., Belous L.F., Prylutskyy Y.I. [et al.] Complexation of C60 fullerene with aromatic drugs. ChemPhysChem, 2013, рр. 568-578. Evstigneev M.P., Buchelnikov A.S., Voronin D.P., Rubin Y.V., Belous L.F., Prylutskyy Y.I. [et al.] Complexation of C60 fullerene with aromatic drugs. ChemPhysChem, 2013, rr. 568-578. Buchelnikov A.S., Kostyukov V.V., Evstigneev M.P., Prylutskyy Y. Mechanism of complexation of the phenothiazine dye methylene blue with fullerene C60. Russ. J. Phys. Chem., 2013, vol. 87 (4), pp. 662-667. Buchelnikov A.S., Kostyukov V.V., Evstigneev M.P., Prylutskyy Y. Mechanism of complexation of the phenothiazine dye methylene blue with fullerene C60. Russ. J. Phys. Chem., 2013, vol. 87 (4), pp. 662-667. Mchedlov-Petrossyan N.O., Klochkov V.K., Andievsky G.V., Ishchenko A.A., Interaction between colloidal particles of C60 hydrosol and cationic dyes. Chem. Phys. Lett., 2001, vol. 341, 2001, pp. 237-244. Mchedlov-Petrossyan N.O., Klochkov V.K., Andievsky G.V., Ishchenko A.A., Interaction between colloidal particles of C60 hydrosol and cationic dyes. Chem. Phys. Lett., 2001, vol. 341, 2001, pp. 237-244. Mukherjee S., Bauri A.K., Bhattacharya S. Spectroscopic and theoretical insights on effective and selective non-covalent binding between fullerenes (C60 and C70) and a designed diporphyrin in solution. Spectrochim. Acta A Mol. Biomol. Spectrosc, 2013, pp. 835-839. Mukherjee S., Bauri A.K., Bhattacharya S. Spectroscopic and theoretical insights on effective and selective non-covalent binding between fullerenes (C60 and C70) and a designed diporphyrin in solution. Spectrochim. Acta A Mol. Biomol. Spectrosc, 2013, pp. 835-839. Reddy B.K., Gadekar S.C., Anand V.G. Non-covalent composites of antiaromatic isophlorin-fullerene. Chem. Commun. (Camb.), 2015, vol. 51, pp. 8276-8279. Reddy B.K., Gadekar S.C., Anand V.G. Non-covalent composites of antiaromatic isophlorin-fullerene. Chem. Commun. (Camb.), 2015, vol. 51, pp. 8276-8279. Varanasi S.R., Guskova O.A., John A., Sommer J.U. Water around fullerene shape amphiphiles: a molecular dynamics simulation study of hydrophobic hydration. J. Chem. Phys., 2015, vol. 142, pp. 224-308. Varanasi S.R., Guskova O.A., John A., Sommer J.U. Water around fullerene shape amphiphiles: a molecular dynamics simulation study of hydrophobic hydration. J. Chem. Phys., 2015, vol. 142, pp. 224-308. Prylutskyy Y.I., Petrenko V.I., Ivankov O.I., Kyzyma O.A., Bulavin L.A., Litsis O.O. [et al.] On the origin of C60 fullerene solubility in aqueous solution. Langmuir, 2014, vol. 30, pp. 3967-3970. Prylutskyy Y.I., Petrenko V.I., Ivankov O.I., Kyzyma O.A., Bulavin L.A., Litsis O.O. [et al.] On the origin of C60 fullerene solubility in aqueous solution. Langmuir, 2014, vol. 30, pp. 3967-3970. Golunski G., Woziwodzka A., Iermak I., Rychlowski M., Piosik J. Modulation of acridine mutagen ICR-191 intercalation to DNA by methylxanthines - analysis with mathematical models. Bioorg Med Chem, 2013. Golunski G., Woziwodzka A., Iermak I., Rychlowski M., Piosik J. Modulation of acridine mutagen ICR-191 intercalation to DNA by methylxanthines - analysis with mathematical models. Bioorg Med Chem, 2013. Ritter U., Prylutskyy Y.I., Davidenko N.A., Cherepanov V.V., Senenko A.I., Marchenko O.A. [et al.] Structural features of highly stable reproducible C60 fullerene aqueous colloid solution probed by various techniques fullerenes. Nanotubes Carbon Nanostruct, 2015, vol. 23 (6), pp. 530-534. Ritter U., Prylutskyy Y.I., Davidenko N.A., Cherepanov V.V., Senenko A.I., Marchenko O.A. [et al.] Structural features of highly stable reproducible C60 fullerene aqueous colloid solution probed by various techniques fullerenes. Nanotubes Carbon Nanostruct, 2015, vol. 23 (6), pp. 530-534. Trott O., Olson A.J., AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J. Comput. Chem,, 2010, vol. 31, pp. 455-461. Trott O., Olson A.J., AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J. Comput. Chem,, 2010, vol. 31, pp. 455-461. Glatter O. A new method for the evaluation of small-angle scattering data. J. Appl. Cryst, 1977, vol. 4, pp. 415-421. Glatter O. A new method for the evaluation of small-angle scattering data. J. Appl. Cryst, 1977, vol. 4, pp. 415-421. Svergun D.I. Determination of the regularization parameter in indirect-transform methods using perceptual criteria. J. Appl. Cryst, 1992, vol. 25, pp. 495-503. Svergun D.I. Determination of the regularization parameter in indirect-transform methods using perceptual criteria. J. Appl. Cryst, 1992, vol. 25, pp. 495-503. Shinohara N., Matsumoto K., Endoh S., Maru J., Nakanishi J. In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles. Toxicol. Lett,, 2009, vol. 191, pp. 289-296. Shinohara N., Matsumoto K., Endoh S., Maru J., Nakanishi J. In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles. Toxicol. Lett,, 2009, vol. 191, pp. 289-296. Prylutskyy Y.I., Buchelnikov A.S., Voronin D.P., Kostjukov V.V., Ritter U., Parkinson J.A. [et al.] C60 fullerene aggregation in aqueous solution. Phys. Chem. Chem. Phys., 2013, vol. 15, pp. 9351-9360. Prylutskyy Y.I., Buchelnikov A.S., Voronin D.P., Kostjukov V.V., Ritter U., Parkinson J.A. [et al.] C60 fullerene aggregation in aqueous solution. Phys. Chem. Chem. Phys., 2013, vol. 15, pp. 9351-9360. Prylutskyy Yu.I., Evstigneev M.P., Cherepanov V.V., Kyzyma O.A., Bulavin L.A., Davidenko N.A. [et al.] Structural organization of C60 fullerene, doxorubicin and their complex in physiological solution as promising antitumor agents. J. Nanopart. Res., 2015, vol. 17, pp. 45-49. Prylutskyy Yu.I., Evstigneev M.P., Cherepanov V.V., Kyzyma O.A., Bulavin L.A., Davidenko N.A. [et al.] Structural organization of C60 fullerene, doxorubicin and their complex in physiological solution as promising antitumor agents. J. Nanopart. Res., 2015, vol. 17, pp. 45-49.