Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54364 Моделирование в биофизике Modelling in biophycis Моделирование в биофизике GENERALIZED ‘UP-SCALED’ MODEL OF COMPLEXATION BETWEEN C60 FULLERENE AND ANTIBIOTIC DOXORUBICIN ОБОБЩЕННАЯ «МАСШТАБИРОВАННАЯ» МОДЕЛЬ КОМПЛЕКСООБРАЗОВАНИЯ ФУЛЛЕРЕНА C60 С АНТИБИОТИКОМ ДОКСОРУБИЦИНОМ Мосунов А А Mosunov A A Воронин Д П Voronin D P Сало В А Salo V A Сидорова М А Sidorova M A Бучельников А С Buchelnikov A S a.buchelnikov@spbu.ru Севастопольский государственный университет ru Sevastopol State University ru Севастопольский государственный университет ru Sevastopol State University ru Севастопольский государственный университет ru Sevastopol State University ru Севастопольский государственный университет ru Sevastopol State University ru Санкт-Петербургский государственный университет ru Saint Petersburg State University ru 25 12 2018 25 12 2018 3 4 777 783 20 12 2018 20 12 2018 https://rusjbpc.ru/en/nauka/article/54364/view

В работе проведен критический анализ опубликованной ранее «масштабированной» модели комплексообразования в системе Фуллерен С60 - Лиганд. Выведены уравнения обобщенной «масштабированной» модели, главной особенностью которых является учет полидисперсности смеси. Проведена аппроксимация опубликованных экспериментальных данных спектрофотометрического титрования в системе Фуллерен С60 - Доксорубицин. Обобщенная модель хорошо описывает минимум на кривой титрования и дает удовлетворительную количественную оценку процесса комплексообразования. Модель может быть применена при исследовании фуллерена С60 как системы доставки лекарственных препаратов к пораженным клеткам.

Previously published ‘up-scaled’ model of complexation in ‘C60 fullerene - Ligand’ system was critically analyzed. The equations of the generalized ‘up-scaled’ model accounting for the polydispersity of the mixture were derived. The approximation of the published experimental data of spectrophotometric titration in the ‘C60 fullerene - Doxorubicin’ system was carried out. The generalized model fits the minimum in the titration curve and gives a satisfactory quantitative evaluation of the complexation process. The model can be used in different studies of C60 fullerene as a drug delivery system to damaged cells.

 агрегация фуллерен C60 доксорубицин статистико-термодинамическая модель aggregation C60 fullerene doxorubucin statistical-thermodynamic model

Montellano A. [et al.] Fullerene C60 as a multifunctional system for drug and gene delivery. Nanoscale, 2011, vol. 3, no. 10, pp. 4035-4041. Montellano A. [et al.] Fullerene C60 as a multifunctional system for drug and gene delivery. Nanoscale, 2011, vol. 3, no. 10, pp. 4035-4041. Prylutska S. [et al.] C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cells drug resistance. Nano Res., 2017, vol. 10, no. 2, pp. 652-671. Prylutska S. [et al.] C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cells drug resistance. Nano Res., 2017, vol. 10, no. 2, pp. 652-671. Borowik A. [et al.] Does C60 fullerene act as a transporter of small aromatic molecules? Colloids Surf. B., 2018, vol. 164, pp. 134-143. Borowik A. [et al.] Does C60 fullerene act as a transporter of small aromatic molecules? Colloids Surf. B., 2018, vol. 164, pp. 134-143. Bilobrov V. [et al.] A novel nanoconjugate of Landomycin A with C60 fullerene for cancer targeted therapy: in vitro studies. Cell. Mol. Bioeng., 2018. Bilobrov V. [et al.] A novel nanoconjugate of Landomycin A with C60 fullerene for cancer targeted therapy: in vitro studies. Cell. Mol. Bioeng., 2018. Boyd P.D.W. [et al.] Fullerene-porphyrin constructs. Acc. Chem. Res., 2005, vol. 38, no. 4, pp. 235-242. Boyd P.D.W. [et al.] Fullerene-porphyrin constructs. Acc. Chem. Res., 2005, vol. 38, no. 4, pp. 235-242. Evstigneev M.P. [et al.] Complexation of C60 fullerene with aromatic drugs. ChemPhysChem, 2013, vol. 14, no. 3, pp. 568-578. Evstigneev M.P. [et al.] Complexation of C60 fullerene with aromatic drugs. ChemPhysChem, 2013, vol. 14, no. 3, pp. 568-578. Evstigneev V.P. [et al.] Complete solution of the problem of one-dimensional non-covalent non-cooperative self-assembly in two-component. J. Chem. Phys., 2011, vol.134, no. 19, Art. No. 194902. Evstigneev V.P. [et al.] Complete solution of the problem of one-dimensional non-covalent non-cooperative self-assembly in two-component. J. Chem. Phys., 2011, vol.134, no. 19, Art. No. 194902. Buchelnikov A.S. [et al.] General statistical-thermodynamical treatment of one-dimensional multicomponent molecular hetero-assembly in solution. Chem. Phys., 2013, vol. 421, pp. 77-83. Buchelnikov A.S. [et al.] General statistical-thermodynamical treatment of one-dimensional multicomponent molecular hetero-assembly in solution. Chem. Phys., 2013, vol. 421, pp. 77-83. Buchelnikov A.S. [et al.] The hetero-association models of non-covalent molecular complexation. Phys. Chem. Chem. Phys., 2018. Buchelnikov A.S. [et al.] The hetero-association models of non-covalent molecular complexation. Phys. Chem. Chem. Phys., 2018. Prylutskyy Yu.I. [et al.] C60 fullerene aggregation in aqueous solution. Phys. Chem. Chem. Phys., 2013, vol. 15, no. 23, pp. 9351-9360. Prylutskyy Yu.I. [et al.] C60 fullerene aggregation in aqueous solution. Phys. Chem. Chem. Phys., 2013, vol. 15, no. 23, pp. 9351-9360.