Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54368 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MICELLAR FORMATION OF NATURAL LIPIDS IN THE POLAR MEDIA МИЦЕЛЛООБРАЗОВАНИЕ ПРИРОДНЫХ ЛИПИДОВ В ПОЛЯРНЫХ СРЕДАХ Шишкина Л. Н. Shishkina L. N. shishkina@sky.chph.ras.ru

доктор химических наук;

doctor of chemical sciences;

 Климович М А Klimovich M A Козлов Михаил Васильевич Kozlov M. V. Плащина И Г Plashchina I G Повх А. Ю. Povkh A. Yu. Институт биохимической физики им. Н.М. Эмануэля РАН Москва Россия N.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences Moscow Russian Federation Институт биохимической физики им. Н.М. Эмануэля РАН ru N.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences ru Институт биохимической физики им. Н.М. Эмануэля РАН Москва Россия N.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences Moscow Russian Federation Институт биохимической физики им. Н.М. Эмануэля РАН ru N.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences ru Институт биохимической физики им. Н.М. Эмануэля РАН Москва Россия N.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences Moscow Russian Federation 25 12 2018 25 12 2018 3 4 799 803 20 12 2018 20 12 2018 https://rusjbpc.ru/en/nauka/article/54368/view

Используя соевый лецитин и липиды, выделенные из органов мышей, как источники природных липидов, проведено сравнительное изучение спонтанной агрегации лецитина в различных по составу и полярности системах и взаимосвязи между составом липидов и размером сформированных из них с помощью ультразвука липосом. Анализ экспериментальных данных позволил предположить, что процесс спонтанного образования мицелл из природных липидов в полярной среде в большей степени зависит от свойств среды, чем от соотношения фракций фосфолипидов в образцах лецитина. Однако при формировании мицелл из природных липидов в водной среде с помощью ультразвука роль состава липидов, в том числе минорных фракций фосфолипидов, существенно возрастает. Понимание механизма мембраногенеза в биологических системах обусловливает необходимость дальнейших исследований механизма мицеллообразования природных липидов в полярных средах.

Comparative analysis of the spontaneous aggregation of lecithin in systems with the different polarity and the interrelation between the lipid composition and size of liposomes formed from them by means of ultrasound are performed used the soy bean lecithin and lipids isolated from organs of mice as sources of the natural lipids. Analysis of the experimental data allows us to suppose that the process of the spontaneous aggregation of micelles from the natural lipids in the polar medium depends on the medium properties to more extent than from the quantitative ratio of the phospholipid fractions in lecithin samples. However, the role of the lipid composition including the minor fractions of phospholipids substantially increases under the micelle formation from the natural lipids in the polar medium by means of ultrasound. The understanding of the membrane-genesis in the biological systems is due to a necessity of further Investigations of the micellar formation mechanism from the natural lipids in the polar media.

 лецитин липиды из органов мышей динамическое рассеяние света состав фосфолипидов lecithin lipids from the organs of mice dynamic light scattering phospholipid composition

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