Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54466 Общая биофизика General biophysics Общая биофизика SELF-ASSEMBLY OF FULLERENE AND ITS COMPLEXES WITH CHEMOTHERAPEUTIC DRUGS - PERSPECTIVE ANTINEOPLASTIC AGENTS САМОАССОЦИАЦИЯ ФУЛЛЕРЕНА И ЕГО КОМПЛЕКСООБРАЗОВАНИЕ С ХИМИОТЕРАПЕВТИЧЕСКИМИ ПРЕПАРАТАМИ - ПЕРСПЕКТИВНОЕ ПРОТИВООПУХОЛЕВОЕ СРЕДСТВО Мосунов А А Mosunov A A aamosunov@sevsu.ru Сало В А Salo V A Воронин Д П Voronin D P Евстигнеев Максим Павлович Evstigneev Maksim Pavlovich

доктор физико-математических наук;

doctor of physical and mathematical sciences;

 Севастопольский государственный университет ru Sevastopol State University ru Севастопольский государственный университет ru Sevastopol State University ru Севастопольский государственный университет ru Sevastopol State University ru Севастопольский государственный университет Sevastopol State University 25 12 2019 25 12 2019 4 4 480 489 20 12 2019 20 12 2019 https://rusjbpc.ru/en/nauka/article/54466/view

Самоассоциация немодифицированного фуллерена С60 и его комплексообразование с химиотерапевтическими препаратами (в частности, доксорубицином, цисплатином и ландомицином А) в водном растворе рассматриваются как возможная ключевая стадия механизма биологической синергии in vivo и in vitro , наблюдаемой при совместном применении препаратов с фуллереном C60. Выполнена полная характеризация водного раствора фуллерена, выдвинуты гипотезы о природе межмолекулярных сил, стабилизирующих конгломераты фуллерена. Проведена оценка размеров кластеров фуллерена, проведено сопоставление этого параметра с биологической активностью препарата и его комплексов с другими биологически активными соединениями. Впервые предложена математическая модель для расчета термодинамических параметров агрегации фуллерена. Проанализированы результаты применения различных физико-химических методов, позволяющих лучше понять природу сил, стабилизирующих комплексы фуллерена С60 с этими препаратами. Предложен физико-химический механизм, позволяющий, по крайней мере частично, объяснить биологическое взаимодействие препарата С60.

The self-association of unmodified C60 fullerene and its complexation with chemotherapeutic drugs (in particular, doxorubicin, cisplatin and landomycin A) in aqueous solution are considered as a possible key stage of the in vivo and in vitro biological synergy mechanism observed with the combined use of drugs with C60 fullerene. A complete characterization of the aqueous fullerene solution has been performed; hypotheses have been put forward on the nature of the intermolecular forces stabilizing the fullerene conglomerates. The sizes of fullerene clusters were estimated, and this parameter was compared with the biological activity of the drug and its complexes with other biologically active compounds. For the first time, a mathematical model is proposed for calculating the thermodynamic parameters of fullerene aggregation. The results of the application of various physicochemical methods are analyzed, which makes it possible for better understanding the nature of the forces stabilizing the complexes of fullerene C60 with these drugs. A physicochemical mechanism is proposed which allows, at least partially, explain the biological interaction of the drug C60.

 фуллерен C60 антибиотик водный раствор агрегация fullerene C60 antibiotic aqueous solution aggregation Работа выполнена при поддержке гранта РФФИ № 18-34-00157 «Агрегация фуллерена С60 с биологически активными соединениями в водной среде как механизм индуцированной лигандами сборки фуллеренового наноконтейнера для адресной доставки лекарственных препаратов».

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