Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54494 Моделирование в биофизике Modelling in biophycis Моделирование в биофизике Investigation of microenvironment selectivity in the bacteriorhodopsin chromophore binding site by retinoid analogs application Исследование селективности окружения хромофор связывающего сайта молекулы бактериородопсина с помощью аналогов ретиноидов Ходонов А. А. Khodonov A. A. khodonov@gmail.com Беликов Н. Е. Belikov N. E. Лукин А. Ю. Lukin A. Yu. Петровская Л. Е. Petrovskaya L. E. lpetr65@yahoo.com Чупин В В Chupin V V Демина О. В. Demina O. V. Институт биохимической физики им. Н.М. Эмануэля РАН Москва Россия N.M. Emanuel Institute of Biochemical Physics RAS Moscow Russian Federation Институт биохимической физики им. Н.М. Эмануэля РАН Москва Россия N.M. Emanuel Institute of Biochemical Physics RAS Moscow Russian Federation МИРЭА - Российский технологический университет Москва Россия MIREA - Russian Technological University Moscow Russian Federation Институт биоорганической химии им. акад. М.М. Шемякина и Ю.А. Овчинникова РАН Москва Россия Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS Moscow Russian Federation Московский физико-технический институт ru Moscow Institute of Physics and Technology ru Институт биохимической физики им. Н.М. Эмануэля РАН Москва Россия N.M. Emanuel Institute of Biochemical Physics RAS Moscow Russian Federation 25 03 2020 25 03 2020 5 1 91 100 20 03 2020 20 03 2020 https://rusjbpc.ru/en/nauka/article/54494/view

На основе результатов собственных исследований и литературных данных была создана база данных “Properties of artificial bacteriorhodopsin analogs. From 1975 to 2019”, версия 2, 2020, суммирующая сведения о способности апобелка (бактериоопсина - BO) к образованию ковалентных и нековалентных комплексов с различными полиеновыми соединениями и об их фотохимических и функциональных свойствах.

Below we are presenting the database “Properties of artificial bacteriorhodopsin analogs. Version 2, 2020. From 1975 to 2019”, which combined information from our and literature data sources with duration period 1975-2020. The comparative analysis of our database, including the information on spectral characteristics and proton transport efficiency of the interaction products about 440 polyenic compounds with BO has shown, that by diversifying the chromophore nature, it is possible to directly change lmax in ABR spectra in a rather wide interval (from 412 to 830 nm), though not all these pigments are capable to cyclic photochemical reactions. In the frames of defined type modification relationship between lmax position in dependence of chromophore nature could be described by linear regression equations in axes (Y) - lmax SB or (SBH+, PLA) / (X) - lmax(CHO). These relationships could be used for the prognosis of the spectral properties of ABR from new retinal derivatives and BO.

 ретиналь-содержащие белки бактериородопсин изомеры и аналоги ретиналя модификации хромофора свойства аналогов бактериородопсина retinal-based proteins bacteriorhodopsin retinal isomers and analogs chromophore group modification bacteriorhodopsin analog properties Работа была частично поддержана РФФИ (проекты № 20-03-00139, №17-00-00165 комфи ).

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