Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 54712 ЭКОЛОГИЧЕСКАЯ БИОФИЗИКА ECOLOGICAL BIOPHYSICS ЭКОЛОГИЧЕСКАЯ БИОФИЗИКА The impact of polychlorinated biphenyls on prooxidant-antioxidant system parameters in hepatopancreas of mussel Mytilus Влияние полихлорированных бифенилов на показатели прооксидантно- антиоксидантной системы гепатопанкреаса мидии Mytilus Galloprovincialis Скуратовская Е Н Skuratovskaya E N skuratovskaya@ibss-ras.ru Сербин А Д Serbin A D Полевой Д М Polevoy D M ФИЦ «Институт биологии южных морей имени А.О. Ковалевского РАН» ru A.O. Kovalevsky Institute of Biology of the Southern Seas of RAS ru Севастопольский государственный университет ru Sevastopol State University ru Крымский федеральный университет им. В.И. Вернадского ru V.I. Vernadsky Crimean Federal University ru 25 12 2021 25 12 2021 6 4 680 685 20 12 2021 20 12 2021 https://rusjbpc.ru/en/nauka/article/54712/view

К наиболее опасным загрязняющим веществам антропогенного происхождения, поступающим из различных источников в прибрежные морские акватории, относятся полихлорированные бифенилы (ПХБ). ПХБ даже в крайне малых дозах вызывают изменение физиолого-биохимических процессов в тканях гидробионтов, оказывают токсическое, мутагенное и канцерогенное действие. Изучение биохимического отклика в тканях двустворчатых моллюсков, обитающих в условиях повышенных концентраций ПХБ в эксперименте, необходимо для понимания механизмов реорганизации метаболизма и адаптивных реакций, возникающих в организме гидробионтов при воздействии токсикантов. В работе изучено влияние ПХБ на показатели прооксидантно-антиоксидантной системы (активность супероксиддимутазы, каталазы, уровень перекисного окисления липидов и окислительной модификации белков) гепатопанкреаса черноморской мидии Mytilus galloprovincialis в условиях острого токсикологического эксперимента. Установлено, что M. galloprovincialis обладает высокой токсикорезистентностью к ПХБ. В то же время при воздействии различных концентраций ПХБ в гепатопанкреасе моллюсков наблюдается развитие окислительного стресса путем смещения проокисдантно-антиоксидантного равновесия в сторону интенсификации процессов перекисного окисления липидов и окислительной модификации белков и повышение активности супероксиддисмутазы как адаптивной компенсаторной реакции организма на действие токсикантов.

Polychlorinated biphenyls (PCBs) are amongst the most dangerous toxic substances of anthropogenic origin incoming into coastal marine waters from various polluting sources. Even extremely small doses of PCBs induce changes in the physiological and biochemical processes in hydrobionts tissues, exert toxic, mutagenic and carcinogenic influences. Investigations of the biochemical response in tissues of the bivalve mollusks, living in a high concentration conditions of PCBs created in the conducted experiment, are of importance to understand the reorganization metabolism mechanisms and adaptive reactions, occurring in the body of hydrobionts being exposed to toxicants. This article is aimed at studying the impact of PCBs on the prooxidant-antioxidant system parameters (activity of superoxide dimutase, catalase, the level of lipid peroxidation and oxidized proteins) in hepatopancreas of the Black Sea mussel Mytilus galloprovincialis in the acute toxicological experiment. It has been established that M. galloprovincialis has high toxicoresistance to PCBs. At the same time observations from our studies showed that, upon exposure to different concentrations of PCBs there was a development of oxidative stress carried out by shifting the prooxidant- antioxidant balance towards the intensification of lipid peroxidation and oxidative modification of proteins also an increase in the SOD activity existing as the adaptive compensatory reaction of the organism to the toxic substances in the hepatopancreas of mollusks.

 полихлорированные бифенилы мидия Mytilus galloprovincialis прооксидантно-антиоксидантная система polychlorinated biphenyls mussel Mytilus galloprovincialis prooxidant-antioxidant system Работа выполнена в рамках темы Государственного задания ФИЦ ИнБЮМ № 121030100028-0, при поддержке РФФИ и г. Севастополя в рамках научного проекта № 18-34-50005 («Наставник»).

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