Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 55176 10.29039/rusjbpc.2022.0570 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ POSSIBLE MOLECULAR MECHANISMS OF POLYSACCHARIDES ACTION IN VIRAL DISEASES ВОЗМОЖНЫЕ МОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ ДЕЙСТВИЯ ПОЛИСАХАРИДОВ ПРИ ВИРУСНЫХ ЗАБОЛЕВАНИЯХ Генералов Е. А. Generalov E. A. generals1179@gmail.com Симоненко Е. Ю. Simonenko E. Yu. Яковенко Л. В. Yakovenko L. V. Московский государственный университет имени М.В. Ломоносова Москва Россия Lomonosov Moscow State University Moscow Russian Federation Московский государственный университет имени М.В. Ломоносова Москва Россия Lomonosov Moscow State University Moscow Russian Federation Московский государственный университет имени М.В. Ломоносова Москва Россия Lomonosov Moscow State University Moscow Russian Federation 24 11 2022 24 11 2022 7 4 613 618 01 08 2022 https://rusjbpc.ru/en/nauka/article/55176/view

За последние десятилетия многочисленными исследованиями установлено, что полисахариды, полученные из различных источников, обладают широким спектром биологических активностей, включая противовирусное действие. В настоящей работе приведены данные, в основном, по противовирусной активности полисахаридов и внутриклеточным сигнальным путям, которые могут участвовать в ее проявлении, указаны некоторые источники и типы полисахаридов, особенности их состава и структуры, основные виды их биологических активностей. В связи с пандемией COVID-19 более подробно рассмотрены особенности возбудителя этого заболевания – вируса SARS-CoV-2, его взаимодействий с клеточными рецепторами, молекулярные механизмы последствий заболевания и возможного лекарственного действия полисахаридов при этом заболевании. Природные полисахариды в перспективе могут оказаться эффективными средствами терапии при различных вирусных заболеваниях, возможно, более эффективными и не имеющими побочных эффектов по сравнению с традиционными противовирусными препаратами.

Over the past decades, numerous studies have established that polysaccharides obtained from various sources have a wide range of biological activities, including antiviral action. This paper presents data mainly on the antiviral activity of polysaccharides and intracellular signaling pathways that may be involved in its manifestation, some sources and types of polysaccharides, features of their composition and structure, and the main types of their biological activities are mentioned. In connection with the COVID-19 pandemic, the features of the causative agent of this disease, the SARS-CoV-2 virus, its interactions with cell receptors, the molecular mechanisms of the consequences of the disease and the possible medicinal effect of polysaccharides in this disease are considered in more detail. In prospect, natural polysaccharides may prove to be effective therapeutic agents for various viral diseases, perhaps more effective and without side effects in comparison with traditional antiviral drugs.

 полисахариды биологическая активность противовирусное действие вирусные заболевания SARS-CoV-2 polysaccharides biological activity antiviral effect viral diseases SARS-CoV-2 Исследование выполнено при поддержке Междисциплинарной научно-образовательной школы Московского университета «Фотонные и квантовые технологии. Цифровая медицина».

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