Russian Journal of Biological Physics and Chemisrty Russian Journal of Biological Physics and Chemisrty АКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ 2499-9962 83071 10.29039/rusjbpc.2023.0590 МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY МЕДИЦИНСКАЯ БИОФИЗИКА И БИОФИЗИЧЕСКАЯ ХИМИЯ ANTIOXIDANT POTENTIAL OF PERITONEAL FLUID IN OVARIAN CANCER АНТИОКСИДАНТНЫЙ ПОТЕНЦИАЛ ПЕРИТОНЕАЛЬНОЙ ЖИДКОСТИ ПРИ РАКЕ ЯИЧНИКОВ Федорова М. В. Fedorova M. V. theklazontag@yandex.ru Вознесенский В. И. Voznesensky V. I. Созарукова М. М. Sozarukova M. M. s_madinam@bk.ru Харченко А. А. Kharchenko A. A. Соснова Е. А. Sosnova E. A. Проскурнина Е. В. Proskurnina E. V. proskurnina@gmail.com Центральный НИИ эпидемиологии Роспотребнадзора Москва Россия Central Research Institute for Epidemiology» of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing Moscow Russian Federation Городская клиническая больница имени Д.Д. Плетнёва Департамента здравоохранения города Москвы Москва Россия Pletnev City Clinical Hospital of the Department of Health of Moscow Moscow Russian Federation Институт общей и неорганической химии им. Н.С. Курнакова РАН Москва Россия Kurnakov Institute of Gentral and Inorganic Chemistry of Russian Academy of Sciences Moscow Russian Federation Городская клиническая больница имени Д.Д. Плетнёва Департамента здравоохранения города Москвы Москва Россия Pletnev City Clinical Hospital of the Department of Health of Moscow Moscow Russian Federation Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет) Москва Россия Sechenov University Moscow Russian Federation Медико-генетический научный центр им. академика Н.П. Бочкова Москва Россия Research Centre for Medical Genetics Moscow Russian Federation 16 05 2024 16 05 2024 8 1 63 70 03 07 2023 https://rusjbpc.ru/en/nauka/article/83071/view

При раке яичников перитонеальная жидкость является активным участником канцерогенеза и свободнорадикального гомеостаза, являясь материалом для исследования локального окислительного стресса. В обсервационное одномоментное неконтролируемое моноцентровое пилотное исследование были включены 48 пациенток 25–74 лет с гистологически подтвержденным раком яичников и доброкачественными новообразованиями яичника. При помощи оригинальной методики, основанной на методе активированной кинетической хемилюминесценции, оценены антиоксидантные профили перитонеальной жидкости с раком яичника и доброкачественными новообразованиями. Для каждого случая из хемилюминограммы рассчитывали два параметра: «уратную» антиоксидантную емкость перитонеальной жидкости Sp, обусловленную сильными антиоксидантами,а так же «альбуминовую» емкость ∆Ib и ∆Ip, обусловленную меркаптоальбумином В перитонеальной жидкости антиоксидантная емкость значимо нарастала в ряду доброкачественные опухоли ˂ высокодифференцированные ˂умеренно- и низкодифференцированные аденокарциномы, приводя к состоянию антиоксидантной избыточности в случае умеренно- и низкодифференцированных аденокарцином. В этом же ряду снижается «альбуминовая» емкость, что свидетельствует об нарастании окислительного стресса в системе глутатиона Таким образом, при раке яичников прогрессирование опухоли приводит к сдвигу в сторону избытка антиоксидантов за счет, возможно, метаболитов самой опухоли.

In ovarian cancer, peritoneal fluid is an active participant in carcinogenesis. The study included 48 patients aged 25–74 years with histologically confirmed ovarian cancer and benign ovarian neoplasms. Using an original technique based on the method of enhanced kinetic chemiluminescence, the antioxidant profiles of peritoneal fluid with ovarian cancer and benign neoplasms were evaluated. In the peritoneal fluid, the antioxidant capacity significantly increased in the series benign tumors > highly differentiated > moderately and poorly differentiated adenocarcinomas, leading to a state of antioxidant excess in the case of moderately and poorly differentiated adenocarcinomas. Thus, in ovarian cancer, tumor progression leads to a shift towards an excess of antioxidants, possibly due to metabolites of the tumor itself.

 антиоксидантная емкость перитонеальная жидкость рак яичников antioxidant capacity peritoneal fluid ovarian cancer

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