Saint Petersburg, St. Petersburg, Russian Federation
Saint Petersburg, St. Petersburg, Russian Federation
With the use of the voltage-clamp technique the involvement of the lipoxygenase oxidation pathway of arachidonic acid in the effect of immunomodulator glutoxim on Na+ transport in frog skin was investigated. It was shown that the inhibitor of all known types of lipoxygenases nordihydroguaiaretic acid decreases the stimulatory effect of glutoxim on Na+ transport in frog skin. The results suggest the involvement of lipoxygenase oxidation pathway of arachidonic acid in glutoxim effect on Na+ transport in frog skin
Na+ transport, glutoxim, arachidonic acid, lipoxygenases
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