EVALUATION OF OXYHEMOGLOBIN DISSOCIATION CURVE FITTING SOME PHYSICAL MEANING FUNCTION
Authors:
1.
Voronezh State University
2.
Voronezh State University
3.
Voronezh State University
Type:
Article
Pages:
from 232
to 236
Status:
Published
Received:
20.06.2016
Accepted:
20.06.2016
Published:
25.06.2016
Subject area:
UDK 577 Материальные основы жизни. Биохимия. Молекулярная биология.Биофизика
Language:
Russian
Keywords:
approximation, dissociation curve of oxyhemoglobin, the coefficient of determination
Abstract (English):
We present numerical approximations of oxyhemoglobin dissociation curve (ODC) by Hüfner’s, Hill’s, Adair’s, Bernard’s, Vysochina’s, Podrabinek-Kamensky’s, Kislyakov’s and Hanin’s functions that have clear physical meaning. The best approximations in the range of oxygen partial pressures between from 0 to 622.5 mm Hg are achieved using Adair’s, Bernard’s and Hill’s equations. These models are characterized by close values of R 2 and common description of the oxygenation process. This fact indirectly indicates a stepwise nature of the hemoglobin oxygen joining due to structural rearrangements of the gemoprotein macromolecule under its ligands binding during equilibrium reactions. The proposed approach to assessing the effectiveness of the ODC approximation may also be used to solve similar problems, i.e., functional testing (regression) models claiming to have a physical meaning.
We present numerical approximations of oxyhemoglobin dissociation curve (ODC) by Hüfner’s, Hill’s, Adair’s, Bernard’s, Vysochina’s, Podrabinek-Kamensky’s, Kislyakov’s and Hanin’s functions that have clear physical meaning. The best approximations in the range of oxygen partial pressures between from 0 to 622.5 mm Hg are achieved using Adair’s, Bernard’s and Hill’s equations. These models are characterized by close values of R 2 and common description of the oxygenation process. This fact indirectly indicates a stepwise nature of the hemoglobin oxygen joining due to structural rearrangements of the gemoprotein macromolecule under its ligands binding during equilibrium reactions. The proposed approach to assessing the effectiveness of the ODC approximation may also be used to solve similar problems, i.e., functional testing (regression) models claiming to have a physical meaning.
Keywords:
approximation, dissociation curve of oxyhemoglobin, the coefficient of determination
approximation, dissociation curve of oxyhemoglobin, the coefficient of determination
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2. Winslow R.M., Swenberg M., Berger R.L. et al. Oxygen equilibrium curve of normal human blood and its evaluation by Adair's. J. Biol. Chemistry, l977, vol. 252, no. 7, pp. 2331-2337.
