Features of the structural self-organization of the C60 fullerene and antitumor drug cisplatin in a physiological solution (0.9% NaCl) were studied by the methods of scanning electron and atomic force microscopy, which can then be used to determine the mechanisms of their specific anticancer activity and practical use in oncology.
60 fullerene, cisplatin, physiological solution, scanning electron microscopy, atomic-force microscopy
1. Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes. Series: Carbon Materials: Chemistry and Physics. Cataldo F., Da Ros T. (Eds.), vol. 1. Springer Netherlands, 2008.
2. Prylutska S.V., Burlaka A.P., Prylutskyy Yu.I., Ritter U., Scharff P. Pristine C60 fullerenes inhibit the rate of tumor growth and metastasis. Exp Oncol, 2011, vol. 33, pp. 162-164.
3. Chen Zh., Mao R., Liu Y. Fullerenes for cancer diagnosis and therapy: preparation, biological and clinical perspectives. Curr Drug Metabolism, 2012, vol. 13, no. 8, pp. 1035-1045.
4. Hirsch A., Brettreich M., Wudl F. Fullerenes: Chemistry and Reactions. NY: Wiley Interscience, 2005.
5. Lucafo M., Pelillo C., Carini M., Da Ros T., Prato M., Sava G. A cationic [60] fullerene derivative reduces invasion and migration of HT-29 CRC cells in vitro at dose free of significant effects on cell survival. Nano-Micro Lett, 2014, vol. 6 (2), pp. 163-168.
6. Gharbi N., Pressac M., Hadchouel M., Szwarc H., Wilson S.R., Moussa F. C60 fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity. Nano Lett, 2005, vol. 5, pp. 2578-2585.
7. Prylutska S.V., Grynyuk I.I., Matyshevska O.P., Prylutskyy Yu.I., Ritter U., Scharff P. Anti-oxidant properties of C60 fullerenes in vitro. Fullerenes Nanotubes Carbon Nanostruct, 2008, vol. 16, pp. 698-705.
8. Mchedlov-Petrossyan N.O. Fullerenes in liquid media: an unsettling intrusion into the solution chemistry. Chem. Rev., 2013, vol. 113, pp. 5149-5193.
9. Ritter U., Prylutskyy Yu.I., Evstigneev M.P., Davidenko N.A., Cherepanov V.V., Senenko A.I., Marchenko O.A., Naumovets A.G. Structural features of highly stable reproducible C60 fullerene aqueous colloid solution probed by various techniques. Fullerenes, Nanotubes, Carbon Nanostruct., 2015, vol. 23, no. 6, pp. 530-534.
10. Prylutskyy Yu.I., Buchelnikov A.S., Voronin D.P., Kostjukov V.V., Ritter U., Parkinson J.A., Evstigneev M.P. C60 fullerene aggregation in aqueous solution. Phys.Chem.Chem.Phys., 2013, vol. 15, pp. 9351-9360.
11. Prylutskyy Yu.I., Petrenko V.I., Ivankov O.I., Kyzyma O.A., Bulavin L.A., Litsis O.O., Evstigneev M.P., Cherepanov V.V., Naumovets A.G., Ritter U. On the origin of C60 fullerene solubility in aqueous solution. Langmuir, 2014, vol. 30, no. 14, pp. 3967-3970.
12. Florea A.-M., Busselberg D. Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects. Cancer, 2011, vol. 3, pp. 1351-1371.
13. Dong X.P., Xiao T.H., Dong H., Jiang N., Zhao X.G. Endostar combined with cisplatin inhibits tumor growth and lymphatic metastasis of lewis lung carcinoma xenografts in mice. Asian Pac. J. Cancer Prev., 2013, vol. 14, pp. 3079-3083.
14. Montellano A., Da Ros T., Bianco A., Prato M. Fullerene C60 as multifunctional system for drug and gene delivery. Nanoscale 2011, vol. 3, pp. 4035-4041.
15. Prylutska S., Bilyy R., Overchuk M., Bychko A., Andreichenko K., Stoika R., Rybalchenko V., Prylutskyy Yu., Tsierkezos N.G., Ritter U. Water-soluble pristine fullerenes C60 increase the specific conductivity and capacity of lipid model membrane and form the channels in cellular plasma membrane. J. Biomed. Nanotechnol., 2012, vol. 8, no. 3, pp. 522-527.
16. Deguchi S., Alargova R.G., Tsujii K. Stable dispersions of fullerenes, C60 and C70 in water. Preparation and characterization. Langmuir, 2001, vol. 17, pp. 6013-6017.
17. Brant J., Lecoanet H., Wiesner M.R. Aggregation and deposition characteristics of fullerene nanoparticles in aqueous systems. J. Nanopart. Res., 2005, vol. 7, pp. 545-553.
