Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
It has been shown that in order to obtain biocompatible magnetite nanoparticles of 14±6 nm in size by the Massart method it is worthwhile to conduct the reaction in an inert atmosphere (argon). The process conditions have been optimized: concentrations of the salts, temperature, reaction time and stirring speed. Sizes, structure and chemical composition of the particles were studied by transmission electron microscopy, electron diffraction and other methods. By intraperitoneal injecting the preparation to intact mice we have shown that the obtained nanoparticles are non-toxic and may be used for biomedical purposes, including as drugs carriers for target delivery to a tumor.
the Massart method, biocompatible magnetite nanoparticles, an inert atmosphere, transmission electron microscopy, toxciity of the preparation
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