Optical absorption and fluorescence of different supramolecular systems based on chlorine e6 (Ce6) were investigated in order to create new medicines used in photodynamic therapy (PDT). The influence of different excipients as polyvinylpyrrolidone (PVP), polyethyleneglycol (PEG), bovine serum albumin (BSA), chitosan, triton X-100 (TX-100), sodium hexametaphosphate (GMP), polydimethyldiallilammonium chloride (PDDA) on spectral characteristics of these systems was studied. It is found out that spectral-fluorescence characteristics of such systems as Ce6-PVP, Ce6-PEG, Ce6-BSA, Ce6-TX-100, Ce6-GMP, Ce6-PDDA confirm disaggregation of molecules of chlorine e6, their consecutive interaction with excipients in solutions and formation of molecular associates and molecular complexes. The system Ce6-chitosan is characterized by aggregation of dye in solution that reduces photochemical activity of a photosensitizer. The obtained results allow to conclude promising method of controlled aggregation of photosensitizers in the composition of supramolecular complexes to create medicines for PDT of predictable photodynamic activity.
chlorine e6, supramolecular systems, spectral characteristics, optical absorption, fluorescence
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