PERSPECTIVE DRUG DELIVERY SYSTEMS BASED ON AMPHIPHILIC POLYPEPTIDES
Authors:
1.
Saint-Petersburg State University
2.
Institute of Macromolecular Compounds, Russian Academy of Sciences
3.
Saint-Petersburg State University
Type:
Article
Pages:
from 90
to 94
Status:
Published
Received:
20.12.2016
Accepted:
20.12.2016
Published:
25.12.2016
Subject area:
UDK 577 Материальные основы жизни. Биохимия. Молекулярная биология.Биофизика
Language:
Russian
Keywords:
amphiphilic polypeptides, biodegradable particles, drug delivery systems, anti-cancer drugs
Abstract (English):
The development of polymeric carriers for delivery of antitumor drugs used for the cancer therapy, is aimed to overcome such negative properties of these drugs, as high toxicity, lack of selectivity and low bioavailability. The amphiphilic polypeptides represent the promising type of polymer to create drug delivery systems. The advantages of these polymers are related to their high biocompatibility, ability to biodegradation and self-assembly. In this work, the results on the synthesis of amphiphilic polypeptides based on α-L-amino acids, the preparation of nanoparticles based on them, the cytotoxicity study, the stability and ability of obtained nanoparticles to cell transfection, as well as the production of encapsulated forms of cytotoxic drugs used for the treatment of colorectal cancer (irinotecan and 5-fluoruracil) are discussed.
The development of polymeric carriers for delivery of antitumor drugs used for the cancer therapy, is aimed to overcome such negative properties of these drugs, as high toxicity, lack of selectivity and low bioavailability. The amphiphilic polypeptides represent the promising type of polymer to create drug delivery systems. The advantages of these polymers are related to their high biocompatibility, ability to biodegradation and self-assembly. In this work, the results on the synthesis of amphiphilic polypeptides based on α-L-amino acids, the preparation of nanoparticles based on them, the cytotoxicity study, the stability and ability of obtained nanoparticles to cell transfection, as well as the production of encapsulated forms of cytotoxic drugs used for the treatment of colorectal cancer (irinotecan and 5-fluoruracil) are discussed.
Keywords:
amphiphilic polypeptides, biodegradable particles, drug delivery systems, anti-cancer drugs
amphiphilic polypeptides, biodegradable particles, drug delivery systems, anti-cancer drugs
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