The status of the pro- and antioxidant systems in the cancer and non-malignized tissues of patients with stomach cancer was studied in depend on age with the comparison the parameters of interest in tumor and stomach mucosa. Thus, the interrelations between pro/antioxidant systems and nucleotides metabolism were analyzed. The cancer and adjacent tissues of 35 patients 40-79 years aged were studied. The activity of purine metabolism enzymes - adenosine deaminase (ADA) and xanthine oxidase (XO), which has the prooxidant ability were determined as well as the activity of antioxidant defense enzyme - glutathione peroxidase (GP) and superoxide dismutase (SOD), and levels of nitrates/nitrites (NOx). The activities of enzymes were measures by spectrophotometery. We found the decreasing of the glutathione link of enzymatic defense system of cell in the hemolysate upon aging of patients with SC on background of intensification of purine metabolism and increasing of NOx level, at that in tumor tissue these changes reveal more expressively in comparison with non-changed tissue. It was found that the age makes the systemic impact on the activity of enzymatic systems and the levels of non-enzymatic parameters of AOS and POS as well the behavior of their relationship in non-transformed and tumor tissues. For patients with SC the strong relationships were found for ADA/SOD, ADA/GPO, SOD/GPO, SOD/NOx, GPO/NOx
age, purines nucleotides, pro-oxidants, antioxidants, reactive oxygen species, gastric cancer
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