A comparative study of the enzymes activity of glucose metabolism and the activity of antioxidant defense enzyme in erythrocytes of patient with advanced tumors of different localizations was carried out. Aim : To evaluate the prognostic relevance of glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, lactate dehydrogenase, glutathione peroxidase activity in erythrocytes. Methods: Enzyme activities were determined spectrophotometrically in red blood cells of 30 patients with advanced gastric cancer, 15 patients with colorectal cancer, 29 patients with lung cancer. Results: It was demonstrated that, the according to the differences of glyceraldehyde-3- phosphate dehydrogenase and glutathione peroxidase activities the erythrocytes were subdivided in two subgroups with glyceraldehyde-3-phosphate dehydrogenase activity increasing and the minimal levels of glutathione peroxidase activity. It was correlated with the 2,3-diphosphoglycerate levels increasing, but not ATP. The glyceraldehyde-3-phosphate dehydrogenase and the glutathione peroxidase erythrocytes activities can to be used as a prognostic markers of red blood cells dysfunction.
glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, lactate dehydrogenase, glutathione peroxidase, cancer, erythrocytes
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