In this paper, the mechanisms of synergistic action of the antitumor antibiotic novatron and unmodified fullerene C60 have been studied. The hetero-association of the antibiotic novatron with fullerene was investigated. The hetero- association constants of the molecules have been determined, allowing one to calculate the change in the biological activity of the preparation when a ligand is added in a certain concentration ratio. The obtained experimental dependences of the amount of heterochromatin granules on the concentration of ligands are well described within the framework of the theory of interceptor-protector action.
C60 fullerene, novatrone, hetero-association
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