One of the important aspects in the study of intermolecular interactions of aromatic biologically active compounds is considered. The solution of this problem is an important stage in the synthesis of new substances, as well as the study of the processes of their complexation. There are a large number of physicochemical factors serving to stabilize such complexes. Hydrogen bonds are one of the possible sources of such stabilization. Experimentally proving presence of H-bond in the complex is a non-trivial task. It is believed that one of methods is to obtain a Raman signal from substances and their complexes with subsequent analysis of spectrograms. To obtain a qualitative signal from a solution with a low concentration of the substance, SERS substrates were used. The testing of this technique on the equipment of the Laboratory of Molecular and Cell Biophysics of the Center for Collective Use of the SevGU is presented in this paper.
biologically active compounds, self-association, Raman spectroscopy, SERS-substrates
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