CELLULAR REACTIONS INDUCED BY NANOCRYSTALLINE TUNGSTEN OXIDE (WO3) EXPOSURE, IN VITRO
Abstract and keywords
Abstract (English):
The development of new functional nanomaterials for the diagnosis and therapy of cancer has attracted increasing attention in recent years. For effective cancer therapy, it is important to develop a new theranostic system based on unique nanomaterials that is capable of responding to a local tumor environment or external stimuli such as temperature, pH, magnetic field, light, etc. One of the most promising materials is nanocrystalline tungsten oxide (WO3), a semiconductor with a wide n-type bandwidth with a chemical type of chromium, which gives it unique photocatalytic properties. Within the framework of this work, we studied the effect of polyvinylpyrrolidone (PVP) - stabilized WO3 nanoparticles on the metabolic and proliferative activity of normal and malignant human cells in vitro .

Keywords:
tungsten oxide nanoparticles, photocatalyst, cytotoxic activity, oxidative stress
Text
Publication text (PDF): Read Download
References

1. Butler T.J., Jackson R.W., Robson J.Y., Owen R.J., Delves H.T., et al. In vivo degradation of tungsten embolisation coils. Br J Radiol., 2000, vol. 73, pp. 601-603.

2. Peuster M., Kaese V., Wuensch G., Wuebbolt P., Niemeyer M., et al. Dissolution of tungsten coils leads to device failure after transcatheter embolisation of pathologic vessels. Heart, 2001, vol. 85, pp. 703-704.

3. Hierholzer J., Depriester C., Fuchs H., Venz S., Maier-Hauff K., et al. Rofo-Fortschr. Rontg, 2002, vol. 174, pp. 328-334.

4. Firouzi M., Poursalehi R., Delavari H., Saba F., & Oghabian M. A. Chitosan coated tungsten trioxide nanoparticles as a contrast agent for X-ray computed tomography. International Journal of Biological Macromolecules, 2017, vol. 98, pp. 479-485.

5. Guandalini G.S., Zhang L., Fornero E., Centeno J.A., Mokashi V.P., et al. Tissue distribution of tungsten in mice following oral exposure to sodium tungstate. Chem Res Toxicol, 2011, vol. 24, pp. 488-493.

6. Witten M.L., Sheppard P.R., Witten B.L. Tungsten toxicity. Chem-Biol Interact, 2012, vol. 196, pp. 87-88.


Login or Create
* Forgot password?