The work provides own and literature data about molecular and biophysical mechanisms of regulation of tumor cells chemoresistance that occur with the participation of reactive oxygen species and antioxidants. The mechanisms of redox signaling and redox homeostasis regulation in normal and tumor cells are considered. Special attention is given to the new strategies for reduction of drug resistance in tumor cells based on redox regulation of cellular processes.
chemoresistance, antioxidants, reactive oxygen species, tumor cells, redox regulation, redox signaling
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