BIODEGRADABLE NANOPARTICLES BASED ON ALIPHATIC POLYESTER AS DRUG DELIVERY SYSTEM
Authors:
1.
Saint-Petersburg State University; Institute of Macromolecular Compounds, Russian Academy of Sciences
2.
Saint-Petersburg State University
3.
N.N. Petrov Research Institute of Oncology of the Ministry of Health
4.
Saint-Petersburg State University
Type:
Article
Pages:
from 622
to 625
Status:
Published
Received:
20.09.2018
Accepted:
20.09.2018
Published:
25.09.2018
Subject area:
UDK 577 Материальные основы жизни. Биохимия. Молекулярная биология.Биофизика
Language:
Russian
Keywords:
biodegradable particles, drug delivery, nanoprecipitation
Abstract (English):
The preparation of nanocontainers for targeted drug delivery is a rapidly developing field of biomedical chemistry. The synthesis of biodegradable block copolymer of polyethylene glycol (PEG-5000) with polylactic acid (PLA) was performed via stannous octoate initiated ring-opening polymerization in bulk. Molecular weights and molecular weight distribution of obtained polymer were studied by Size exclusion chromatography (SEC). For the characterization of obtained samples 1H-NMR was used. Polymer particles with the sizes from 40 to 200 nm were prepared by nanoprecipitation method. Dioxadet was encapsulated in biodegradable polymer containers this cytotoxic drug used for the treatment of ovarian cancer. The encapsulation efficiency for the developed systems ranged from 46 to 83%, the loading content was equal to 230 μg mg-1 of particles.
The preparation of nanocontainers for targeted drug delivery is a rapidly developing field of biomedical chemistry. The synthesis of biodegradable block copolymer of polyethylene glycol (PEG-5000) with polylactic acid (PLA) was performed via stannous octoate initiated ring-opening polymerization in bulk. Molecular weights and molecular weight distribution of obtained polymer were studied by Size exclusion chromatography (SEC). For the characterization of obtained samples 1H-NMR was used. Polymer particles with the sizes from 40 to 200 nm were prepared by nanoprecipitation method. Dioxadet was encapsulated in biodegradable polymer containers this cytotoxic drug used for the treatment of ovarian cancer. The encapsulation efficiency for the developed systems ranged from 46 to 83%, the loading content was equal to 230 μg mg-1 of particles.
Keywords:
biodegradable particles, drug delivery, nanoprecipitation
biodegradable particles, drug delivery, nanoprecipitation
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